INT264969

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.64
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PIK3CD) signal transduction (PIK3CD) plasma membrane (PIK3CD)
Anatomy Link Frequency
adipocytes 1
PIK3CD (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 134 99.84 Very High Very High Very High
analgesia 40 96.76 Very High Very High Very High
antagonist 30 94.84 High High
Enkephalin 80 83.76 Quite High
Delta opioid receptors 4 50.44 Quite High
narcan 16 44.32 Quite Low
mu opioid receptor 2 43.92 Quite Low
cytokine 7 40.88 Quite Low
withdrawal 25 10.24 Low Low
IPN 39 5.04 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 68 99.28 Very High Very High Very High
Sarcoma 1 94.08 High High
Fibrosarcoma 8 70.80 Quite High
Cancer 18 59.68 Quite High
Nociception 48 52.36 Quite High
Apoptosis 9 50.00 Quite Low
Disease 1 10.80 Low Low
Inflammatory Pain 39 5.04 Very Low Very Low Very Low
INFLAMMATION 92 5.00 Very Low Very Low Very Low
Pain 58 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, our results demonstrate that PI3K is partially implicated in LPS-activated adipocytes.
Localization (implicated) of PI3K in adipocytes associated with obesity
1) Confidence 0.50 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.26 Pain Relevance 0
A PI3K inhibitor LY294002 significantly suppressed AKT phosphorylation and VEGF expression, which is similar to PO treatment, implying that PI3K is related to and downstream of VEGF in the cells.
Localization (related) of PI3K
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0.28 Pain Relevance 0
Examination of PDCD10-PI3K colocalization in cell
Localization (colocalization) of PI3K
3) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0
Mycobacteria stimulate FPR-dependent intracellular calcium mobilization and PI3K-dependent release of opioid peptides
Localization (mobilization) of PI3K associated with opioid
4) Confidence 0.20 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.05 Pain Relevance 0.56
Mycobacteria stimulate FPR-dependent intracellular calcium mobilization and PI3K-dependent release of opioid peptides
Localization (release) of PI3K associated with opioid
5) Confidence 0.20 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.05 Pain Relevance 0.58

General Comments

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