INT26497

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Context Info
Confidence 0.44
First Reported 1989
Last Reported 1989
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.50
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, MMP2) extracellular region (TNF, MMP2) plasma membrane (TNF, MMP2)
intracellular (TNF) extracellular matrix organization (TNF) peptidase activity (MMP2)
Anatomy Link Frequency
granulation 2
TNF (Homo sapiens)
MMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 100.00 Very High Very High Very High
dexamethasone 3 99.84 Very High Very High Very High
cINOD 6 97.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 6 100.00 Very High Very High Very High
Necrosis 6 100.00 Very High Very High Very High
INFLAMMATION 6 97.18 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggest that steroidal anti-inflammatory drugs suppress a rapid collagen breakdown in granulation tissue through their inhibitory actions--one of which is the suppression of active gelatinase production enhanced by cytokines including TNF.
TNF Positive_regulation (enhanced) of Gene_expression (production) of gelatinase in granulation associated with inflammation, cinod and cytokine
1) Confidence 0.44 Published 1989 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 2559182 Disease Relevance 0.48 Pain Relevance 0.27
Recombinant human tumor necrosis factor-alpha (TNF) markedly enhanced the production of gelatinases, especially high-Mr active gelatinase.
TNF Positive_regulation (enhanced) of Gene_expression (production) of high-Mr active gelatinase associated with necrosis and cancer
2) Confidence 0.44 Published 1989 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 2559182 Disease Relevance 0.51 Pain Relevance 0.24
Recombinant human tumor necrosis factor-alpha (TNF) markedly enhanced the production of gelatinases, especially high-Mr active gelatinase.
tumor necrosis factor-alpha Positive_regulation (enhanced) of Gene_expression (production) of high-Mr active gelatinase associated with necrosis and cancer
3) Confidence 0.39 Published 1989 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 2559182 Disease Relevance 0.51 Pain Relevance 0.24

General Comments

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