INT264970

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Context Info
Confidence 0.11
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 4.21
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR2) plasma membrane (TLR2) intracellular (TLR2)
cytoplasm (TLR2)
TLR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 201 97.44 Very High Very High Very High
Inflammation 114 94.72 High High
Pain 84 93.76 High High
Enkephalin 120 92.96 High High
Endogenous opioid 6 91.80 High High
IPN 57 84.64 Quite High
Hyperalgesia 15 80.40 Quite High
Pain threshold 3 70.32 Quite High
analgesia 60 48.60 Quite Low
antagonist 45 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 114 94.72 High High
Pain 87 93.76 High High
Inflammatory Pain 57 84.64 Quite High
Hyperalgesia 18 80.40 Quite High
Nociception 72 77.28 Quite High
Arthritis 9 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Post Operative Pain 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This requires activation of FPR as well as intracellular Ca2+ mobilization and PI3K activation, while TLR-2 and -4 do not seem to be involved.
Positive_regulation (activation) of Localization (mobilization) of TLR-2
1) Confidence 0.11 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 1.39 Pain Relevance 1.11
This requires activation of FPR as well as intracellular Ca2+ mobilization and PI3K activation, while TLR-2 and -4 do not seem to be involved.
Positive_regulation (requires) of Localization (mobilization) of TLR-2
2) Confidence 0.11 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 1.41 Pain Relevance 1.13
This requires activation of FPR as well as intracellular Ca2+ mobilization and PI3K activation, while TLR-2 and -4 do not seem to be involved.
Positive_regulation (activation) of Localization (mobilization) of TLR-2
3) Confidence 0.11 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 1.41 Pain Relevance 1.13

General Comments

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