INT26500

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Context Info
Confidence 0.78
First Reported 1989
Last Reported 2011
Negated 2
Speculated 7
Reported most in Abstract
Documents 201
Total Number 216
Disease Relevance 110.57
Pain Relevance 46.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP2) extracellular space (MMP2) extracellular region (MMP2)
proteinaceous extracellular matrix (MMP2) plasma membrane (MMP2) nucleus (MMP2)
Anatomy Link Frequency
macrophages 8
bladder 8
plaques 5
endothelial cells 5
fibroblasts 4
MMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 3582 100.00 Very High Very High Very High
cytokine 1069 100.00 Very High Very High Very High
Pain 121 100.00 Very High Very High Very High
Calcitonin gene-related peptide 11 99.96 Very High Very High Very High
cOX1 1 99.90 Very High Very High Very High
Arthritis 285 99.84 Very High Very High Very High
dexamethasone 178 99.84 Very High Very High Very High
cINOD 221 99.82 Very High Very High Very High
Chronic pancreatitis 101 99.72 Very High Very High Very High
COX-2 inhibitor 234 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bladder Cancer 592 100.00 Very High Very High Very High
Myocardial Infarction 115 100.00 Very High Very High Very High
Ventricular Remodeling 1 100.00 Very High Very High Very High
Pancreatic Cancer 103 99.92 Very High Very High Very High
Osteoarthritis 345 99.84 Very High Very High Very High
Seronegative Spondarthritis 116 99.84 Very High Very High Very High
Skin Cancer 75 99.84 Very High Very High Very High
Major Depressive Disorder 25 99.84 Very High Very High Very High
Cancer 4455 99.80 Very High Very High Very High
Repression 21 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here the concurrence of morphological changes and the expression of matrix metalloproteinase-2 (MMP-2) in damaged discs from individuals suffering joint dysfunction was investigated.
Gene_expression (expression) of MMP-2 in joint associated with metalloproteinase and arthropathy
1) Confidence 0.78 Published 1999 Journal Arch. Oral Biol. Section Abstract Doc Link 10348355 Disease Relevance 0.46 Pain Relevance 0.26
Here the concurrence of morphological changes and the expression of matrix metalloproteinase-2 (MMP-2) in damaged discs from individuals suffering joint dysfunction was investigated.
Gene_expression (expression) of matrix metalloproteinase-2 in joint associated with metalloproteinase and arthropathy
2) Confidence 0.78 Published 1999 Journal Arch. Oral Biol. Section Abstract Doc Link 10348355 Disease Relevance 0.46 Pain Relevance 0.26
The expression and tissue immunolocalization of MMP-2 in fibrocartilages from these condyles was examined histochemically.
Spec (examined) Gene_expression (expression) of MMP-2 in fibrocartilages associated with metalloproteinase
3) Confidence 0.78 Published 2000 Journal J. Oral Pathol. Med. Section Abstract Doc Link 10947247 Disease Relevance 0.53 Pain Relevance 0.52
In the present study, we have examined the histological relationship between osteoarthritic changes on articular cartilage with or without articular disc perforation, and MMP-2 expression, in 85 mandibular condyles from cadavers.
Gene_expression (expression) of MMP-2 in mandibular condyles associated with cadaver, metalloproteinase and osteoarthritis
4) Confidence 0.78 Published 2000 Journal J. Oral Pathol. Med. Section Abstract Doc Link 10947247 Disease Relevance 0.54 Pain Relevance 0.50
Expression of matrix metalloproteinase-2 in osteoarthritic fibrocartilage from human mandibular condyle.
Gene_expression (Expression) of matrix metalloproteinase-2 in fibrocartilage associated with metalloproteinase and osteoarthritis
5) Confidence 0.78 Published 2000 Journal J. Oral Pathol. Med. Section Title Doc Link 10947247 Disease Relevance 0.53 Pain Relevance 0.50
However, MMP-2 expression and osteoarthritic changes in internal derangement of the temporomandibular joint are unknown.
Gene_expression (expression) of MMP-2 in temporomandibular joint associated with snapping jaw, metalloproteinase and osteoarthritis
6) Confidence 0.78 Published 2000 Journal J. Oral Pathol. Med. Section Abstract Doc Link 10947247 Disease Relevance 0.53 Pain Relevance 0.38
Furthermore, DMSO effectively inhibited capillary tube formation; this mechanism would be due to suppression of matrix metalloproteinase-2 (MMP-2) production.
Gene_expression (production) of matrix metalloproteinase-2 in tube associated with metalloproteinase
7) Confidence 0.76 Published 2003 Journal Biol. Pharm. Bull. Section Abstract Doc Link 12951474 Disease Relevance 0.40 Pain Relevance 0.40
Furthermore, DMSO effectively inhibited capillary tube formation; this mechanism would be due to suppression of matrix metalloproteinase-2 (MMP-2) production.
Gene_expression (production) of MMP-2 in tube associated with metalloproteinase
8) Confidence 0.76 Published 2003 Journal Biol. Pharm. Bull. Section Abstract Doc Link 12951474 Disease Relevance 0.39 Pain Relevance 0.40
Immunohistochemistry was used to demonstrate expression of MMP-2, -9, vascular endothelial growth factor (VEGF) and microvessel density (MVD).
Gene_expression (expression) of MMP-2
9) Confidence 0.76 Published 2006 Journal Gynecol. Obstet. Invest. Section Body Doc Link 16837781 Disease Relevance 0.09 Pain Relevance 0
RESULTS: In both eutopic and ectopic endometrium of adenomyosis, the expression of MMP-2, -9 as well as VEGF was significantly greater than in normal endometrium (p < 0.05).
Gene_expression (expression) of MMP-2 in endometrium
10) Confidence 0.76 Published 2006 Journal Gynecol. Obstet. Invest. Section Body Doc Link 16837781 Disease Relevance 0.08 Pain Relevance 0
Matrix metalloproteinase-2 and -9 expression correlated with angiogenesis in human adenomyosis.
Gene_expression (expression) of Matrix metalloproteinase-2 associated with dismenorea and metalloproteinase
11) Confidence 0.76 Published 2006 Journal Gynecol. Obstet. Invest. Section Title Doc Link 16837781 Disease Relevance 0.39 Pain Relevance 0.47
Zymography demonstrated: (a) expression of MMP-2 and MMP-9 activity was downregulated along with elevated dose of indomethacin.
Gene_expression (expression) of MMP-2
12) Confidence 0.76 Published 2005 Journal J. Neurooncol. Section Abstract Doc Link 15803368 Disease Relevance 0.30 Pain Relevance 0.19
Epicatechin was used as the standard and the total flavonoid contents of EOE, TCE and TBE are expressed as mg epicatechin equivalents (ECE)/g dry weight of the extract.


Gene_expression (expressed) of TBE
13) Confidence 0.75 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2170955 Disease Relevance 0.15 Pain Relevance 0
The total phenolic contents of EOE, TCE and TBE are expressed in terms of mg gallic acid equivalent (GAE)/g dry weight of the plant extract.
Gene_expression (expressed) of TBE
14) Confidence 0.75 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2170955 Disease Relevance 0 Pain Relevance 0
The aim of the present study was to evaluate the regulation of MMP-2 (gelatinase-A) and MMP-3 (stromelysin) produced by cultured ovine nucleus pulposus (NP) cells stimulated with interleukin-1beta (IL-1beta).
Gene_expression (produced) of gelatinase-A in nucleus pulposus
15) Confidence 0.75 Published 2003 Journal Eur Spine J Section Abstract Doc Link 12592549 Disease Relevance 0.35 Pain Relevance 0.26
During form deprivation in mammals (tree shrews and primates), the sclera weakens due to increased degradation and reduced synthesis of extracellular matrices (ECM) and collagens, and an increased synthesis of matrix metalloproteinase and gelatinase A in the sclera [20,21].
Gene_expression (synthesis) of gelatinase A in sclera associated with metalloproteinase
16) Confidence 0.75 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994335 Disease Relevance 0.39 Pain Relevance 0.08
MMP-2, -3, and IL-8 mRNA expression was up-regulated by the compression, and both MMP-1 and -3 protein expression and MMP-2 activity were detected.
Gene_expression (expression) of MMP-2
17) Confidence 0.75 Published 2007 Journal J. Dent. Res. Section Abstract Doc Link 17652211 Disease Relevance 1.04 Pain Relevance 0.72
Moreover, a non-selective COX inhibitor indomethacin also suppressed the expression of MMP-2.
Gene_expression (expression) of MMP-2
18) Confidence 0.73 Published 2001 Journal FEBS Lett. Section Abstract Doc Link 11728453 Disease Relevance 0.44 Pain Relevance 0.33
Non-steroidal anti-inflammatory drugs inhibit matrix metalloproteinase-2 expression via repression of transcription in lung cancer cells.
Gene_expression (expression) of matrix metalloproteinase-2 in lung associated with lung cancer, inflammation, repression, metalloproteinase and cinod
19) Confidence 0.73 Published 2001 Journal FEBS Lett. Section Title Doc Link 11728453 Disease Relevance 0.48 Pain Relevance 0.32
However, the inhibitory effect of NS398 is not fully dependent on inhibition of COX-2 because a high concentration of NS398 was needed to suppress MMP-2 expression and addition of prostaglandin E2 only partially reversed the action of NS398.
Gene_expression (expression) of MMP-2
20) Confidence 0.73 Published 2001 Journal FEBS Lett. Section Abstract Doc Link 11728453 Disease Relevance 0.44 Pain Relevance 0.33

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