INT26501

Context Info Confidence 0.67 First Reported 1989 Last Reported 2011 Negated 1 Speculated 2 Reported most in Body Documents 51 Total Number 52 Disease Relevance 39.00 Pain Relevance 15.16

peptidase activity (MMP2) extracellular space (MMP2) extracellular region (MMP2) proteinaceous extracellular matrix (MMP2) plasma membrane (MMP2) nucleus (MMP2)

Anatomy Link Frequency bladder 6 connective tissue 6 fibroblasts 4 arterioles 2 granulation 2 MMP2 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 838 100.00 cytokine 344 100.00 Inflammatory mediators 39 100.00 COX-2 inhibitor 66 99.96 cINOD 124 99.40 Inflammation 598 99.12 dexamethasone 226 99.12 IPN 8 98.76 Kinase C 2 96.68 Angina 34 94.44

Disease Link Frequency Relevance Heat INFLAMMATION 727 100.00 Syndrome 87 100.00 Cancer 918 99.96 Malignant Neoplastic Disease 53 99.84 Necrosis 48 99.84 Metastasis 193 99.82 Disease 272 99.68 Adenocarcinoma 19 99.68 Bladder Cancer 149 99.48 Recurrence 48 99.40

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Key:

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Mutation

Event

Anatomy

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Speculation

Pain term

Disease term

MMP-2, -3, and IL-8 mRNA expression was up-regulated by the compression, and both MMP-1 and -3 protein expression and MMP-2 activity were detected.

Positive_regulation (up) of Gene_expression (expression) of MMP-2

1) Confidence 0.67 Published 2007 Journal J. Dent. Res. Section Abstract Doc Link 17652211 Disease Relevance 1.04 Pain Relevance 0.72

Vasala et al. [4] demonstrated an overexpression of MMP2 immunohistochemically.

Positive_regulation (overexpression) of Gene_expression (overexpression) of MMP2

2) Confidence 0.65 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 1.10 Pain Relevance 0.17

MMP2 overexpression correlated with bladder cancer stage, but not with grade.

Positive_regulation (overexpression) of Gene_expression (overexpression) of MMP2 in bladder associated with bladder cancer

3) Confidence 0.65 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 1.15 Pain Relevance 0.15

MMP2 expressions were significantly increased in cases with recurrence and distant metastasis (P = 0.047 and 0.048, respectively).

Positive_regulation (increased) of Gene_expression (expressions) of MMP2 associated with metastasis and recurrence

4) Confidence 0.62 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 1.10 Pain Relevance 0

MMP2 expression was significantly increased in cases with recurrence and distant metastasis (P = 0.047 and 0.048, respectively).

Positive_regulation (increased) of Gene_expression (expression) of MMP2 associated with metastasis and recurrence

5) Confidence 0.62 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2965128 Disease Relevance 1.07 Pain Relevance 0.25

The results suggest that human lung adenocarcinoma G1, through an elevated expression of the activated forms of both MMP-2 and MMP-9, may represent a more invasive phenotype than less differentiated tumors G2 or G3.

Positive_regulation (elevated) of Gene_expression (expression) of MMP-2 in lung associated with adenocarcinoma and cancer

6) Confidence 0.57 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12044784 Disease Relevance 0.75 Pain Relevance 0.26

IL-1beta was a potent catabolic mediator for the NP cells, resulting in the production of elevated levels of MMP-2 and -3 in culture.

Positive_regulation (resulting) of Gene_expression (production) of MMP-2

7) Confidence 0.54 Published 2003 Journal Eur Spine J Section Abstract Doc Link 12592549 Disease Relevance 0.13 Pain Relevance 0.06

Cells overexpressing PLD isozyme enhance matrix metalloproteinase-2 expression and tumor cell invasion and form metastases in syngeneic mice [12], [13].

Positive_regulation (enhance) of Gene_expression (expression) of matrix metalloproteinase-2 associated with cancer, metalloproteinase and metastasis

8) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 1.11 Pain Relevance 0.05

Gelatin and casein zymography indicated that elevated levels of proMMP-2 and proMMP-3 were present in media samples in response to the IL-1beta treatment.

Positive_regulation (elevated) of Gene_expression (levels) of proMMP-2

9) Confidence 0.47 Published 2003 Journal Eur Spine J Section Abstract Doc Link 12592549 Disease Relevance 0.28 Pain Relevance 0.20

During form deprivation in mammals (tree shrews and primates), the sclera weakens due to increased degradation and reduced synthesis of extracellular matrices (ECM) and collagens, and an increased synthesis of matrix metalloproteinase and gelatinase A in the sclera [20,21].

Positive_regulation (increased) of Gene_expression (synthesis) of gelatinase A in sclera associated with metalloproteinase

10) Confidence 0.45 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994335 Disease Relevance 0.39 Pain Relevance 0.08

Recently, we reported that HCSM cells increase their expression and activation of MMP-2 in response to treatment with pathogenic A?

Positive_regulation (increase) of Gene_expression (expression) of MMP-2

11) Confidence 0.45 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1557842 Disease Relevance 1.18 Pain Relevance 0.41

Increased expression and activation of matrix metalloproteinase 2 (MMP-2) is associated with neuroinflammation [37].

Positive_regulation (Increased) of Gene_expression (expression) of MMP-2 associated with metalloproteinase

12) Confidence 0.45 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1557842 Disease Relevance 1.39 Pain Relevance 0.65

MMP-2, -3, and IL-8 mRNA expression was up-regulated by the compression, and both MMP-1 and -3 protein expression and MMP-2 activity were detected.

Positive_regulation (-) of Gene_expression (expression) of MMP-2

13) Confidence 0.45 Published 2007 Journal J. Dent. Res. Section Abstract Doc Link 17652211 Disease Relevance 1.04 Pain Relevance 0.72

Kanayama et al. [33] found an elevated mRNA expression of MMP2 and MMP9 in tissue of muscular invasive bladder tumours compared to non-invasive tumours.

Positive_regulation (elevated) of Gene_expression (expression) of MMP2 in bladder associated with cancer and bladder cancer

14) Confidence 0.44 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 1.11 Pain Relevance 0.16

It has been described in the literature that elevated expressions of MMP2 and MMP9 in bladder cancer tissue at the mRNA and protein level are associated with advanced tumour stage, grade, and a decreased survival rate [32-34].

Positive_regulation (elevated) of Gene_expression (expressions) of MMP2 in bladder associated with cancer and bladder cancer

15) Confidence 0.44 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.93 Pain Relevance 0.17

Similarly, APF treatment resulted in significantly decreased MMP2 mRNA levels in nontransfected or non-target transfected but not CKAP4 siRNA-transfected cells (Figure 6B-D) (p < .01 for nontransfected and p < .05 for non-target transfected cells, regardless of whether target gene mRNA expression was calculated relative to ?

Spec (whether) Positive_regulation (resulted) of Spec (whether) Gene_expression (levels) of MMP2 mRNA

16) Confidence 0.43 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 0.39 Pain Relevance 0

Immunohistochemistry with antibodies against MMP-2 and elastic van Gieson staining revealed that arterioles express high levels of MMP-2 within 3 months of symptom onset and that intimal hyperplasia proceeded rapidly between 4 and 7 months, resulting in severe vascular narrowing.

Positive_regulation (levels) of Gene_expression (express) of MMP-2 in arterioles associated with hyperplasia

17) Confidence 0.43 Published 2005 Journal J. Pathol. Section Abstract Doc Link 15685708 Disease Relevance 0.99 Pain Relevance 0.53

Those findings were further supported by studies in prostate cancer patients with skeletal metastases who had elevated serum levels of and mmp-2 mmp-9.14,15

Positive_regulation (elevated) of Gene_expression (levels) of mmp-2 associated with prostate cancer and metastasis

18) Confidence 0.42 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 1.61 Pain Relevance 0

MMP2 expression was higher in malignant gland compared to normal gland, especially nearby the basement membrane (BM).

Positive_regulation (higher) of Gene_expression (expression) of MMP2 in basement membrane associated with malignant neoplastic disease

19) Confidence 0.42 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2965128 Disease Relevance 1.10 Pain Relevance 0.28

Furthermore, MMP2 expression was higher in malignant gland compared to normal gland, especially nearby the BM (Figure 2C).

Positive_regulation (higher) of Gene_expression (expression) of MMP2 in gland associated with malignant neoplastic disease

20) Confidence 0.42 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 0.48 Pain Relevance 0

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