INT26502

Context Info Confidence 0.58 First Reported 1989 Last Reported 2010 Negated 0 Speculated 2 Reported most in Abstract Documents 39 Total Number 42 Disease Relevance 21.45 Pain Relevance 9.42

peptidase activity (MMP2) extracellular space (MMP2) extracellular region (MMP2) proteinaceous extracellular matrix (MMP2) plasma membrane (MMP2) nucleus (MMP2)

Anatomy Link Frequency HDFs 4 tube 4 lung 4 lymph node 2 bladder 2 MMP2 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 862 100.00 cINOD 40 99.98 cytokine 291 99.48 dexamethasone 30 99.42 Inflammation 244 98.12 Snapping jaw 7 97.68 Osteoarthritis 212 97.60 Kinase C 3 97.08 Pain 46 95.20 Arthritis 50 94.00

Disease Link Frequency Relevance Heat INFLAMMATION 305 99.86 Major Depressive Disorder 25 99.84 Repression 8 99.80 Cancer 878 99.76 Fibrosarcoma 28 99.60 Breast Cancer 177 99.54 Death 60 99.50 Lung Injury 1 99.48 Disease 176 99.40 Bladder Cancer 101 99.40

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, DMSO effectively inhibited capillary tube formation; this mechanism would be due to suppression of matrix metalloproteinase-2 (MMP-2) production.

Negative_regulation (suppression) of Gene_expression (production) of MMP-2 in tube associated with metalloproteinase

1) Confidence 0.58 Published 2003 Journal Biol. Pharm. Bull. Section Abstract Doc Link 12951474 Disease Relevance 0.40 Pain Relevance 0.40

Non-steroidal anti-inflammatory drugs inhibit matrix metalloproteinase-2 expression via repression of transcription in lung cancer cells.

Negative_regulation (inhibit) of Gene_expression (expression) of matrix metalloproteinase-2 in lung associated with lung cancer, inflammation, repression, metalloproteinase and cinod

2) Confidence 0.55 Published 2001 Journal FEBS Lett. Section Title Doc Link 11728453 Disease Relevance 0.48 Pain Relevance 0.32

Taken together, these results indicate that non-steroidal anti-inflammatory drugs suppress MMP-2 expression via repression of transcription and support the notion that COX inhibitors may be useful in inhibition and/or prevention of metastasis.

Negative_regulation (suppress) of Gene_expression (expression) of MMP-2 associated with inflammation, repression, cinod and metastasis

3) Confidence 0.55 Published 2001 Journal FEBS Lett. Section Abstract Doc Link 11728453 Disease Relevance 0.58 Pain Relevance 0.33

Moreover, a non-selective COX inhibitor indomethacin also suppressed the expression of MMP-2.

Negative_regulation (suppressed) of Gene_expression (expression) of MMP-2

4) Confidence 0.55 Published 2001 Journal FEBS Lett. Section Abstract Doc Link 11728453 Disease Relevance 0.44 Pain Relevance 0.33

Anti-integrin beta1 or beta3 antibody pretreatment of monocytes led to a general decrease in MMP-2/-9 protein expression.

Negative_regulation (decrease) of Gene_expression (expression) of MMP-2 in monocytes

5) Confidence 0.47 Published 2007 Journal Biomaterials Section Abstract Doc Link 16979234 Disease Relevance 0.24 Pain Relevance 0.40

Furthermore, DMSO effectively inhibited capillary tube formation; this mechanism would be due to suppression of matrix metalloproteinase-2 (MMP-2) production.

Negative_regulation (suppression) of Gene_expression (production) of matrix metalloproteinase-2 in tube associated with metalloproteinase

6) Confidence 0.42 Published 2003 Journal Biol. Pharm. Bull. Section Abstract Doc Link 12951474 Disease Relevance 0.40 Pain Relevance 0.40

Zymography demonstrated: (a) expression of MMP-2 and MMP-9 activity was downregulated along with elevated dose of indomethacin.

Negative_regulation (downregulated) of Gene_expression (expression) of MMP-2

7) Confidence 0.42 Published 2005 Journal J. Neurooncol. Section Abstract Doc Link 15803368 Disease Relevance 0.30 Pain Relevance 0.19

MMP-2, -3, and IL-8 mRNA expression was up-regulated by the compression, and both MMP-1 and -3 protein expression and MMP-2 activity were detected.

Negative_regulation (detected) of Gene_expression (expression) of MMP-2

8) Confidence 0.41 Published 2007 Journal J. Dent. Res. Section Abstract Doc Link 17652211 Disease Relevance 1.00 Pain Relevance 0.71

However, the inhibitory effect of NS398 is not fully dependent on inhibition of COX-2 because a high concentration of NS398 was needed to suppress MMP-2 expression and addition of prostaglandin E2 only partially reversed the action of NS398.

Negative_regulation (suppress) of Gene_expression (expression) of MMP-2

9) Confidence 0.41 Published 2001 Journal FEBS Lett. Section Abstract Doc Link 11728453 Disease Relevance 0.44 Pain Relevance 0.33

Protein expression levels of both MMP-9 and MMP-2 were inhibited and TIMP-1 protein level was enhanced by these flavonoid glycosides [33].

Negative_regulation (inhibited) of Gene_expression (expression) of MMP-2

10) Confidence 0.38 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0.21 Pain Relevance 0.11

Although the difference of MMP2 expression is significant in terms of the recurrence and metastatic status, the MMP9 expression was not associated with tumor stage, lymph node status, metastasis status, recurrence or not.

Negative_regulation (difference) of Gene_expression (expression) of MMP2 in lymph node associated with cancer, metastasis and recurrence

11) Confidence 0.38 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 1.72 Pain Relevance 0.06

Downregulation of MMP2 expression by APF in T24 bladder cancer cells via CKAP4

Negative_regulation (Downregulation) of Gene_expression (expression) of MMP2 in bladder associated with bladder cancer

12) Confidence 0.37 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 0.32 Pain Relevance 0

The results suggest that steroidal anti-inflammatory drugs suppress a rapid collagen breakdown in granulation tissue through their inhibitory actions--one of which is the suppression of active gelatinase production enhanced by cytokines including TNF.

Negative_regulation (suppression) of Gene_expression (production) of gelatinase in granulation associated with inflammation, cinod and cytokine

13) Confidence 0.37 Published 1989 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 2559182 Disease Relevance 0.49 Pain Relevance 0.27

Dexamethasone and hydrocortisone strongly suppressed TNF-mediated production of high-Mr active gelatinase, whereas indomethacin, piroxicam and mepacrine had no effect.

Negative_regulation (suppressed) of Gene_expression (production) of high-Mr active gelatinase associated with dexamethasone

14) Confidence 0.37 Published 1989 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 2559182 Disease Relevance 0.50 Pain Relevance 0.26

Similarly, APF treatment resulted in significantly decreased MMP2 mRNA levels in nontransfected or non-target transfected but not CKAP4 siRNA-transfected cells (Figure 6B-D) (p < .01 for nontransfected and p < .05 for non-target transfected cells, regardless of whether target gene mRNA expression was calculated relative to ?

Spec (whether) Negative_regulation (decreased) of Spec (whether) Gene_expression (levels) of MMP2 mRNA

15) Confidence 0.37 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 0.39 Pain Relevance 0

As shown in Figure 6A, APF treatment decreased MMP2 protein expression in nontransfected or non-target siRNA-transfected, but not CKAP4 siRNA-transfected, T24 cells.

Negative_regulation (decreased) of Gene_expression (expression) of MMP2 in T24

16) Confidence 0.37 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 0.36 Pain Relevance 0

Sulindac and its metabolites down-regulated Akt phosphorylation, inhibited MMP-2 production, and significantly inhibited invasiveness of human glioblastoma cells.

Negative_regulation (inhibited) of Gene_expression (production) of MMP-2 associated with glioblastoma

17) Confidence 0.37 Published 2005 Journal J. Cell. Biochem. Section Abstract Doc Link 15546138 Disease Relevance 0.66 Pain Relevance 0.21

Sulfated glucosamine inhibits MMP-2 and MMP-9 expressions in human fibrosarcoma cells.

Negative_regulation (inhibits) of Gene_expression (expressions) of MMP-2 associated with fibrosarcoma

18) Confidence 0.31 Published 2007 Journal Bioorg. Med. Chem. Section Title Doc Link 17498959 Disease Relevance 0.53 Pain Relevance 0.24

Kim et al. report the inhibitory effect of chitooligosaccharides (COS) on activation and expression of matrix metalloproteinase-2 (MMP-2) in primary human dermal fibroblasts (HDFs) for the first time.

Negative_regulation (effect) of Gene_expression (expression) of MMP-2 in fibroblasts associated with metalloproteinase

19) Confidence 0.28 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0 Pain Relevance 0.08

COS with 3–5 kDa exhibited the highest inhibitory effect on MMP-2 activity in HDFs, and protein expression of MMP-2 was also inhibited by COS with same molecular weight.

Negative_regulation (inhibited) of Gene_expression (expression) of MMP-2 in HDFs

20) Confidence 0.28 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0 Pain Relevance 0.05

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