INT265066

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.59
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Reln) extracellular space (Reln) extracellular region (Reln)
cell adhesion (Reln) proteinaceous extracellular matrix (Reln) molecular_function (Reln)
Anatomy Link Frequency
brainstem 1
Reln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central grey 180 99.96 Very High Very High Very High
medulla 25 99.66 Very High Very High Very High
Morphine 40 95.04 Very High Very High Very High
Endogenous opioid 5 86.64 High High
Anterior cingulate 15 77.92 Quite High
parabrachial 15 68.16 Quite High
Opioid 10 55.68 Quite High
amygdala 25 53.60 Quite High
Thalamus 10 5.00 Very Low Very Low Very Low
midbrain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 185 99.96 Very High Very High Very High
Cognitive Disorder 5 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
with the fact that rlPAG does not seem to be activated in response to predator
Positive_regulation (activated) of rlPAG
1) Confidence 0.02 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.22 Pain Relevance 0.11
The rlPAG is also significantly targeted by hypothalamic districts that
Positive_regulation (targeted) of rlPAG
2) Confidence 0.02 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0 Pain Relevance 0
that a small number of brainstem sites appear to innervate the rlPAG.
Positive_regulation (innervate) of rlPAG in brainstem associated with medulla
3) Confidence 0.02 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.27 Pain Relevance 0.21
referred to as the rostrolateral PAG (rlPAG), should be responsible for this
Positive_regulation (responsible) of rlPAG associated with central grey
4) Confidence 0.02 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.44 Pain Relevance 0.97
In contrast to the rlPAG, the dlPAG upregulates
Positive_regulation (upregulates) of rlPAG
5) Confidence 0.02 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.66 Pain Relevance 0.43

General Comments

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