INT26507

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Context Info
Confidence 0.02
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.95
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
pyramidal cell 1
vas deferens 1
U (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 5 99.24 Very High Very High Very High
COX2 2 99.24 Very High Very High Very High
Inflammation 4 99.04 Very High Very High Very High
Pyramidal cell 112 98.84 Very High Very High Very High
antagonist 11 97.60 Very High Very High Very High
Cannabinoid receptor 6 96.88 Very High Very High Very High
Enkephalin 7 92.08 High High
interneuron 8 91.80 High High
narcan 3 90.00 High High
analgesia 2 89.68 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 6 99.04 Very High Very High Very High
Contagious Ecthyma 14 96.40 Very High Very High Very High
Depression 30 82.08 Quite High
Pressure And Volume Under Development 4 66.64 Quite High
Cognitive Disorder 2 61.32 Quite High
Peritonitis 2 57.92 Quite High
Repression 8 50.00 Quite Low
Targeted Disruption 7 5.00 Very Low Very Low Very Low
Neuroblastoma 2 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the rabbit vas deferens preparations (RVD), on the other hand, U-50488H, KK-3 and KK-4 showed weak inhibitory effects and the inhibition of U-50488H and KK-3 were antagonized by norbinaltorphimine.
Negative_regulation (inhibition) of U-50488H in vas deferens
1) Confidence 0.02 Published 1989 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 2559186 Disease Relevance 0 Pain Relevance 1.11
The stronger suppression of uAUGs with respect to uORFs can be partially explained by the fact that initiation at the main ORF may occur only by leaky scanning in uAUG-containing transcripts, whereas both leaky scanning and ribosome reinitiation may allow initiation at the AUG of main uORF-containing transcripts (53).
Negative_regulation (suppression) of uAUGs associated with contagious ecthyma
2) Confidence 0.01 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.26 Pain Relevance 0
Carbachol caused a robust decrease in uIPSC amplitudes in all three types of cell pairs.
Negative_regulation (decrease) of uIPSC
3) Confidence 0.00 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2916217 Disease Relevance 0 Pain Relevance 0.21
M2-type muscarinic receptors were responsible for the reduction in uIPSC amplitudes in FSBC– and AAC–pyramidal cell pairs, while an antagonist of CB1 cannabinoid receptors recovered the suppression in RSBC–pyramidal cell pairs.
Negative_regulation (reduction) of uIPSC in pyramidal cell associated with cannabinoid receptor, antagonist and pyramidal cell
4) Confidence 0.00 Published 2010 Journal The European Journal of Neuroscience Section Abstract Doc Link PMC2916217 Disease Relevance 0.14 Pain Relevance 0.53
In vivo activity of a phospholipase C inhibitor, 1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione (U73122), in acute and chronic inflammatory reactions.
Negative_regulation (inhibitor) of U73122 associated with inflammation and analgesic
5) Confidence 0.00 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 14730005 Disease Relevance 0.32 Pain Relevance 0.27
To investigate the role of phospholipase C (PLC) in inflammatory processes, we tested 1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione (U73122), a widely used PLC inhibitor, in several in vitro and in vivo assays.
Negative_regulation (inhibitor) of U73122 associated with inflammation
6) Confidence 0.00 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14730005 Disease Relevance 0.23 Pain Relevance 0.09

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