INT26507

Context Info Confidence 0.02 First Reported 1989 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 6 Disease Relevance 0.95 Pain Relevance 2.21

Anatomy Link Frequency pyramidal cell 1 vas deferens 1 U (Mus musculus)

Pain Link Frequency Relevance Heat Analgesic 5 99.24 COX2 2 99.24 Inflammation 4 99.04 Pyramidal cell 112 98.84 antagonist 11 97.60 Cannabinoid receptor 6 96.88 Enkephalin 7 92.08 interneuron 8 91.80 narcan 3 90.00 analgesia 2 89.68

Disease Link Frequency Relevance Heat INFLAMMATION 6 99.04 Contagious Ecthyma 14 96.40 Depression 30 82.08 Pressure And Volume Under Development 4 66.64 Cognitive Disorder 2 61.32 Peritonitis 2 57.92 Repression 8 50.00 Targeted Disruption 7 5.00 Neuroblastoma 2 5.00 Volume Depletion And Dehydration 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the rabbit vas deferens preparations (RVD), on the other hand, U-50488H, KK-3 and KK-4 showed weak inhibitory effects and the inhibition of U-50488H and KK-3 were antagonized by norbinaltorphimine.

Negative_regulation (inhibition) of U-50488H in vas deferens

1) Confidence 0.02 Published 1989 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 2559186 Disease Relevance 0 Pain Relevance 1.11

The stronger suppression of uAUGs with respect to uORFs can be partially explained by the fact that initiation at the main ORF may occur only by leaky scanning in uAUG-containing transcripts, whereas both leaky scanning and ribosome reinitiation may allow initiation at the AUG of main uORF-containing transcripts (53).

Negative_regulation (suppression) of uAUGs associated with contagious ecthyma

2) Confidence 0.01 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.26 Pain Relevance 0

Carbachol caused a robust decrease in uIPSC amplitudes in all three types of cell pairs.

Negative_regulation (decrease) of uIPSC

3) Confidence 0.00 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2916217 Disease Relevance 0 Pain Relevance 0.21

M2-type muscarinic receptors were responsible for the reduction in uIPSC amplitudes in FSBC– and AAC–pyramidal cell pairs, while an antagonist of CB1 cannabinoid receptors recovered the suppression in RSBC–pyramidal cell pairs.

Negative_regulation (reduction) of uIPSC in pyramidal cell associated with cannabinoid receptor, antagonist and pyramidal cell

4) Confidence 0.00 Published 2010 Journal The European Journal of Neuroscience Section Abstract Doc Link PMC2916217 Disease Relevance 0.14 Pain Relevance 0.53

In vivo activity of a phospholipase C inhibitor, 1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione (U73122), in acute and chronic inflammatory reactions.

Negative_regulation (inhibitor) of U73122 associated with inflammation and analgesic

5) Confidence 0.00 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 14730005 Disease Relevance 0.32 Pain Relevance 0.27

To investigate the role of phospholipase C (PLC) in inflammatory processes, we tested 1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione (U73122), a widely used PLC inhibitor, in several in vitro and in vivo assays.

Negative_regulation (inhibitor) of U73122 associated with inflammation

6) Confidence 0.00 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14730005 Disease Relevance 0.23 Pain Relevance 0.09

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