INT265087

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.61
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Trpa1)
Trpa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
c fibre 18 97.88 Very High Very High Very High
Inflammation 61 83.36 Quite High
qutenza 10 75.56 Quite High
Spinal cord 1 72.12 Quite High
bradykinin 1 62.00 Quite High
Inflammatory mediators 3 57.68 Quite High
nociceptor 11 50.00 Quite Low
TRP channel 7 50.00 Quite Low
agonist 19 43.88 Quite Low
allodynia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 64 83.36 Quite High
Nociception 12 71.12 Quite High
Neuropathic Pain 9 5.00 Very Low Very Low Very Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low
Nervous System Injury 1 5.00 Very Low Very Low Very Low
Ganglion Cysts 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given that there are functional interactions between TRPA1 and TRPV1 in vitro and in vivo (Bandell et al., 2004; Bautista et al., 2006; Jeske et al., 2006; Akopian et al., 2007; Ruparel et al., 2007), it is interesting to speculate that a TRPA1/TRPV1 interaction may be responsible for the lower heat thresholds seen in the polymodal C-fibres that express TRPA1 in comparison to those that do not.
Spec (may) Regulation (responsible) of TRPA1 Binding (interaction) of associated with c fibre
1) Confidence 0.44 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2658012 Disease Relevance 0.61 Pain Relevance 0.58

General Comments

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