INT2651

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Context Info
Confidence 0.70
First Reported 1978
Last Reported 2010
Negated 18
Speculated 14
Reported most in Abstract
Documents 403
Total Number 417
Disease Relevance 95.72
Pain Relevance 206.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
plasma 81
pituitary 31
anterior pituitary 25
hypothalamus 24
arcuate nucleus 19
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 440 100.00 Very High Very High Very High
Enkephalin 355 100.00 Very High Very High Very High
Morphine 325 100.00 Very High Very High Very High
narcan 275 100.00 Very High Very High Very High
antagonist 252 100.00 Very High Very High Very High
Pain 189 100.00 Very High Very High Very High
Endogenous opioid 171 100.00 Very High Very High Very High
opiate 152 100.00 Very High Very High Very High
Hippocampus 118 100.00 Very High Very High Very High
Analgesic 112 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 475 100.00 Very High Very High Very High
Aids-related Complex 66 100.00 Very High Very High Very High
Hyperalgesia 122 99.98 Very High Very High Very High
Hemorrhage 78 99.98 Very High Very High Very High
Pressure Volume 2 Under Development 36 99.98 Very High Very High Very High
Hypoglycemia 5 99.98 Very High Very High Very High
Fever 6 99.96 Very High Very High Very High
Weight Gain 13 99.90 Very High Very High Very High
Sleep Disorders 8 99.90 Very High Very High Very High
Endotoxemia 2 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This increase in POMC mRNA may contribute to the shift in parental behavior that occurs in male and female juvenile rats.
Positive_regulation (increase) of POMC mRNA in juvenile
1) Confidence 0.70 Published 1999 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 10446343 Disease Relevance 0 Pain Relevance 0.14
We report, for the first time, that a 5-day treatment with delta 9-tetrahydrocannabinol (5 mg/kg per day, i.p.) increased (38%) POMC mRNA levels in the arcuate nucleus of the hypothalamus but was without effect in the anterior lobe of the pituitary.
Positive_regulation (increased) of POMC mRNA in arcuate nucleus
2) Confidence 0.70 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9128838 Disease Relevance 0 Pain Relevance 0.21
Intrathecal administrations of the POMC vector elevated spinal beta-endorphin levels, as manifested in a significantly elevated pain threshold for the CCI limbs.
Positive_regulation (elevated) of beta-endorphin in limbs associated with pain threshold, injury and intrathecal
3) Confidence 0.70 Published 2002 Journal Gene Ther. Section Abstract Doc Link 12215892 Disease Relevance 0.85 Pain Relevance 0.55
RESULT: EOAD could increase beta-endorphin, NO and the amount of masculine cell expression of Proopiomelanocortin mRNA significantly in hypothalamus and brainstem of rats.
Positive_regulation (increase) of beta-endorphin in brainstem
4) Confidence 0.70 Published 2002 Journal Zhongguo Zhong Yao Za Zhi Section Body Doc Link 12776573 Disease Relevance 0.09 Pain Relevance 0
In situ hybridization histochemistry with a cRNA probe for POMC indicates that POMC-containing cells are located within the confines of the arcuate nucleus both in control and in alpha-methyldopa-treated rats, and confirms the increase in POMC mRNA in the latter.
Positive_regulation (increase) of POMC mRNA in arcuate nucleus
5) Confidence 0.70 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8677016 Disease Relevance 0.32 Pain Relevance 0.17
Intrathecal pTRE2-POMC/pTel-off electroporation elevated spinal beta-endorphin levels, as manifested in a significantly elevated pain threshold for chronic constriction injury limbs.
Positive_regulation (elevated) of beta-endorphin in limbs associated with pain threshold, eae, injury and intrathecal
6) Confidence 0.70 Published 2004 Journal Gene Ther. Section Abstract Doc Link 15116065 Disease Relevance 0.53 Pain Relevance 0.93
Similar changes in the biosynthesis of the pituitary hormones were seen in rats suffering from chronic arthritic pain for 3 weeks: there was an approximately 80% increase in POMC mRNA levels in the anterior pituitary which was associated with an increase in the levels of ir-beta-endorphin in this lobe and an increase in the plasma levels of ir-beta-endorphin.
Positive_regulation (increase) of ir-beta-endorphin in plasma associated with pain and arthritis
7) Confidence 0.70 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 2942792 Disease Relevance 0.55 Pain Relevance 0.10
Similar changes in the biosynthesis of the pituitary hormones were seen in rats suffering from chronic arthritic pain for 3 weeks: there was an approximately 80% increase in POMC mRNA levels in the anterior pituitary which was associated with an increase in the levels of ir-beta-endorphin in this lobe and an increase in the plasma levels of ir-beta-endorphin.
Positive_regulation (increase) of POMC mRNA in plasma associated with pain and arthritis
8) Confidence 0.70 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 2942792 Disease Relevance 0.57 Pain Relevance 0.10
Similar changes in the biosynthesis of the pituitary hormones were seen in rats suffering from chronic arthritic pain for 3 weeks: there was an approximately 80% increase in POMC mRNA levels in the anterior pituitary which was associated with an increase in the levels of ir-beta-endorphin in this lobe and an increase in the plasma levels of ir-beta-endorphin.
Positive_regulation (increase) of ir-beta-endorphin in plasma associated with pain and arthritis
9) Confidence 0.70 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 2942792 Disease Relevance 0.54 Pain Relevance 0.10
Lymphocytes upregulate signal sequence-encoding proopiomelanocortin mRNA and beta-endorphin during painful inflammation in vivo.
Positive_regulation (upregulate) of beta-endorphin in Lymphocytes associated with pain and inflammation
10) Confidence 0.70 Published 2007 Journal J. Neuroimmunol. Section Title Doc Link 17223201 Disease Relevance 0.36 Pain Relevance 0.83
Lymphocytes upregulate signal sequence-encoding proopiomelanocortin mRNA and beta-endorphin during painful inflammation in vivo.
Positive_regulation (upregulate) of proopiomelanocortin in Lymphocytes associated with pain and inflammation
11) Confidence 0.70 Published 2007 Journal J. Neuroimmunol. Section Title Doc Link 17223201 Disease Relevance 0.36 Pain Relevance 0.82
Fos expression (an indicator of neuronal activation) in the arcuate nucleus was colocalized in beta-endorphin neurones in both proestrus and parturient rats, but the number of positive cells did not increase during parturition, suggesting lack of activation of beta-endorphin neurones at birth.
Positive_regulation (activation) of beta-endorphin in neuronal
12) Confidence 0.70 Published 2002 Journal J. Neuroendocrinol. Section Abstract Doc Link 12372001 Disease Relevance 0 Pain Relevance 0.09
In U-50,488H-abstinent rats, the concentration of beta-endorphin was increased in pons-medulla and amygdala, whereas the concentration of beta-endorphin did not change in the pituitary gland, plasma and peripheral tissues.
Positive_regulation (increased) of beta-endorphin in pons associated with medulla and amygdala
13) Confidence 0.70 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8113998 Disease Relevance 0 Pain Relevance 0.59
In U-50,488H-tolerant rats, the concentration of beta-endorphin was increased in hippocampus, corpus striatum, pituitary gland, plasma, kidneys and adrenals compared with vehicle-injected controls.
Positive_regulation (increased) of beta-endorphin in plasma associated with hippocampus
14) Confidence 0.70 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8113998 Disease Relevance 0 Pain Relevance 0.66
Drospirenone increases central and peripheral beta-endorphin in ovariectomized female rats.
Positive_regulation (increases) of beta-endorphin
15) Confidence 0.70 Published 2007 Journal Menopause Section Title Doc Link 17075429 Disease Relevance 0 Pain Relevance 0.14
Estradiol valerate replacement increased beta-endorphin and allopregnanolone levels in all brain areas analyzed and in plasma/serum.
Positive_regulation (increased) of beta-endorphin in brain
16) Confidence 0.70 Published 2007 Journal Menopause Section Body Doc Link 17075429 Disease Relevance 0 Pain Relevance 0
During naloxone-precipitated abstinence beta-endorphin levels were increased in corpus striatum, midbrain and cortex.
Positive_regulation (increased) of beta-endorphin in corpus striatum associated with narcan and midbrain
17) Confidence 0.70 Published 1991 Journal Brain Res. Section Abstract Doc Link 1933285 Disease Relevance 0 Pain Relevance 1.78
In addition, in naloxone-precipitated abstinence beta-endorphin levels were decreased in pituitary gland and hippocampus but increased in plasma.
Positive_regulation (increased) of beta-endorphin in pituitary gland associated with narcan and hippocampus
18) Confidence 0.70 Published 1991 Journal Brain Res. Section Abstract Doc Link 1933285 Disease Relevance 0 Pain Relevance 2.00
We observed a significant increase of beta-endorphin and substance P hypothalamic levels, and a significant decrease of beta-endorphin concentrations in the immune cells.
Positive_regulation (increase) of beta-endorphin in immune cells associated with substance p
19) Confidence 0.70 Published 1996 Journal Brain Res. Bull. Section Abstract Doc Link 8842411 Disease Relevance 0.25 Pain Relevance 0.30
Recurrent exposure to intermittent electrical foot-shock (30 min, twice daily) for 7 days caused an increase in immunoreactive (ir) dynorphin and ir-alpha-neo-endorphin in lumbar and cervical (but not thoracic) spinal cord as measured 16 h following the final session.
Positive_regulation (increase) of ir-alpha-neo-endorphin in spinal cord associated with dynorphin, shock and spinal cord
20) Confidence 0.70 Published 1987 Journal Brain Res. Section Abstract Doc Link 2886190 Disease Relevance 0.26 Pain Relevance 0.46

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