INT26514

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Context Info
Confidence 0.41
First Reported 1989
Last Reported 2007
Negated 1
Speculated 3
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 1.18
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Anatomy Link Frequency
leukocyte 4
Mme (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 6 100.00 Very High Very High Very High
substance P 5 100.00 Very High Very High Very High
Opioid 5 100.00 Very High Very High Very High
Chronic pancreatitis 4 100.00 Very High Very High Very High
Pain 3 100.00 Very High Very High Very High
IPN 1 99.40 Very High Very High Very High
Enkephalin 1 98.16 Very High Very High Very High
Neuropeptide 1 98.16 Very High Very High Very High
qutenza 4 79.84 Quite High
Spinal cord 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Pain 4 100.00 Very High Very High Very High
Pancreatitis 4 100.00 Very High Very High Very High
Inflammatory Pain 1 99.40 Very High Very High Very High
Arthritis 3 92.16 High High
Bronchial Hyperreactivity 2 70.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, LPS-induced alterations in airway responses to bronchial constrictors, neutral endopeptidase (NEP) gene expression, leukocyte counts, and SP and calcitonin gene-related peptide (CGRP) levels were determined.
Spec (determined) Regulation (determined) of Gene_expression (expression) of NEP in leukocyte associated with calcitonin gene-related peptide
1) Confidence 0.41 Published 2003 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 12738685 Disease Relevance 0.07 Pain Relevance 0.29
In addition, LPS-induced alterations in airway responses to bronchial constrictors, neutral endopeptidase (NEP) gene expression, leukocyte counts, and SP and calcitonin gene-related peptide (CGRP) levels were determined.
Spec (determined) Regulation (determined) of Gene_expression (expression) of neutral endopeptidase in leukocyte associated with calcitonin gene-related peptide
2) Confidence 0.36 Published 2003 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 12738685 Disease Relevance 0.07 Pain Relevance 0.29
These results suggest that the enhanced efficiency of exogenous opioids or endogenous enkephalins, reported to occur in this model of chronic inflammatory pain, are not directly related to changes in mu and delta opioid binding sites or steady state levels of NEP.
Regulation (changes) of Gene_expression (levels) of NEP associated with ipn, enkephalin and opioid
3) Confidence 0.24 Published 1989 Journal Neuropharmacology Section Abstract Doc Link 2559347 Disease Relevance 0.41 Pain Relevance 0.76
So far, expression of SP receptors NK-2R, NK-3R, the SP-encoding gene preprotachykinin A (PPT-A), and the SP degradation enzyme neutral endopeptidase (NEP) and their relation to pain in CP have not been determined.
Neg (not) Spec (determined) Regulation (determined) of Spec (determined) Gene_expression (expression) of NEP associated with pain, chronic pancreatitis and substance p
4) Confidence 0.07 Published 2007 Journal Ann. Surg. Section Abstract Doc Link 17968170 Disease Relevance 0.63 Pain Relevance 0.93

General Comments

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