INT265150

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Context Info
Confidence 0.13
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.30
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Chrm1) signal transducer activity (Chrm1)
Chrm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 7 100.00 Very High Very High Very High
nMDA receptor 8 98.72 Very High Very High Very High
GABAergic 4 98.52 Very High Very High Very High
agonist 42 93.52 High High
Glutamate 15 92.32 High High
Central nervous system 10 91.92 High High
antagonist 5 86.88 High High
tetrodotoxin 28 77.84 Quite High
Peripheral nervous system 1 70.48 Quite High
medulla 1 57.76 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 74 99.98 Very High Very High Very High
Hypoglycemia 39 99.02 Very High Very High Very High
Body Weight 4 84.08 Quite High
Cerebellar Diseases 4 76.32 Quite High
Nash(non-alcoholic Steatohepatitis) 24 44.48 Quite Low
Muscle Hypotonia 2 19.48 Low Low
Cognitive Disorder 17 15.32 Low Low
Hyperglycemia 5 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Brain Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The main objective of the present study was to determine whether hypoglycemia as a consequence of insulin therapy in diabetes altered the binding parameters of Muscarinic M1, M3 receptors and gene expression of ?
Spec (whether) Regulation (altered) of Gene_expression (parameters) of Muscarinic M1 associated with hypoglycemia and diabetes mellitus
1) Confidence 0.13 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2845573 Disease Relevance 1.30 Pain Relevance 0.20
mol/L) had no effect on the picrotoxin-enhanced M1 mACh receptor desensitization (Fig. 2b; Table 1).
Neg (no) Regulation (effect) of Gene_expression (desensitization) of M1 mACh receptor
2) Confidence 0.10 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.53
Effects of ionotropic glutamate receptor blockade on picrotoxin-enhanced M1 mACh receptor desensitization
Regulation (Effects) of Gene_expression (desensitization) of M1 mACh receptor associated with glutamate receptor
3) Confidence 0.08 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.49

General Comments

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