INT265208

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.99
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Th17 cells 2
T cells 1
thd (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 55 98.40 Very High Very High Very High
addiction 1 91.60 High High
psoriasis 5 87.08 High High
rheumatoid arthritis 14 86.52 High High
Central nervous system 93 74.64 Quite High
Arthritis 6 72.60 Quite High
cytokine 66 69.76 Quite High
Inflammatory response 7 62.72 Quite High
dexamethasone 3 37.60 Quite Low
tolerance 5 20.44 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 62 98.40 Very High Very High Very High
Death 25 97.64 Very High Very High Very High
Apoptosis 22 90.88 High High
Demyelinating Disease 181 87.64 High High
Multiple Sclerosis 191 87.20 High High
Psoriasis 5 87.08 High High
Rheumatoid Arthritis 14 86.52 High High
Graft Vs Host Disease 3 85.40 High High
Autoimmune Disease 91 85.12 High High
Colitis 3 78.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, vitamin D3 may be a “helper” in the generation of IL-10-producing cells in an inflammatory environment but the effect of IL-10 is not essential for vitamin D3's negative regulation of TH17 generation.


Negative_regulation (regulation) of TH17 associated with inflammation
1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.17 Pain Relevance 0.05
Under TH17-polarizing conditions, 1,25(OH)2D3 helps to increase the numbers of IL-10-producing T cells, but 1,25(OH)2D3's negative regulation of TH17 development is still defined in the IL-10?
Negative_regulation (regulation) of TH17 in T cells
2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2944871 Disease Relevance 0.29 Pain Relevance 0.04
However, unlike IL-27, 1,25(OH)2D3's ability to inhibit the development TH17 cells was independent on the STAT1.
Negative_regulation (inhibit) of TH17
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.09 Pain Relevance 0
This inhibition of Th17 differentiation could not be attributed to increased cell death.
Negative_regulation (inhibition) of Th17 associated with death
4) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0.28 Pain Relevance 0.03
These findings revealed the importance of B7.1 and B7.2 as negative regulators of human Th17 development.
Negative_regulation (regulators) of Th17
5) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0.95 Pain Relevance 0.22
Interestingly, we found that anti-CD28 mAb significantly enhanced IL-17 production upon re-stimulation, demonstrating that CD28 co-stimulation did not inhibit fully differentiated Th17 cells (Fig. 2B).
Negative_regulation (inhibit) of Th17 in Th17 cells
6) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0 Pain Relevance 0
Bcl-6, a transcriptional repressor, binds to the promoters of the Th1 and Th17 cell transcriptional regulators T-bet and RORgammat and represses IFN-?
Negative_regulation (regulators) of Th17 in Th17 cell
7) Confidence 0.00 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.22 Pain Relevance 0.08

General Comments

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