INT265212

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Context Info
Confidence 0.10
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il17a) extracellular region (Il17a) plasma membrane (Cd28)
Anatomy Link Frequency
T cells 2
Cd28 (Mus musculus)
Il17a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 12 97.28 Very High Very High Very High
abatacept 2 49.68 Quite Low
Inflammation 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
psoriasis 1 5.00 Very Low Very Low Very Low
Crohn's disease 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 9 5.00 Very Low Very Low Very Low
Multiple Sclerosis 7 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 4 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Lyme Disease 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As depicted in Fig. 1, anti-CD28 mAb strongly inhibited IL-17 production by anti-CD3 stimulated CD4+ T cells as determined by intracellular cytokine staining and enzyme-linked immunosorbent assay (ELISA) (Fig. 1, A–B and data not shown).
CD28 mAb Negative_regulation (inhibited) of Gene_expression (production) of IL-17 in T cells associated with cytokine
1) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0 Pain Relevance 0.09

General Comments

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