INT265213

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Context Info
Confidence 0.13
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.93
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ctla4, Cd86) Golgi apparatus (Ctla4)
Anatomy Link Frequency
dendritic cells 1
T-cell 1
Ctla4 (Mus musculus)
Cd86 (Mus musculus)
Pain Link Frequency Relevance Heat
abatacept 17 100.00 Very High Very High Very High
psoriasis 4 94.32 High High
rheumatoid arthritis 19 93.20 High High
cytokine 51 61.20 Quite High
Inflammation 16 5.00 Very Low Very Low Very Low
Arthritis 14 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 4 94.32 High High
Rheumatoid Arthritis 19 93.20 High High
Systemic Lupus Erythematosus 156 87.76 High High
Autoimmune Disease 24 71.40 Quite High
Renal Disease 66 53.52 Quite High
Disease 50 23.64 Low Low
Recurrence 18 5.00 Very Low Very Low Very Low
INFLAMMATION 16 5.00 Very Low Very Low Very Low
Infection 15 5.00 Very Low Very Low Very Low
Apoptosis 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In APC/T cell co-cultures, mature dendritic cells (DC) were less efficient than immature DC in their ability to support Th17 cell differentiation, while CTLA4-Ig, an agent blocking CD28/B7 and CTLA4/B7 interactions, facilitated both murine and human Th17 differentiation.
CTLA4 Binding (interactions) of B7 in dendritic cells
1) Confidence 0.13 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2658739 Disease Relevance 0.14 Pain Relevance 0
Therefore a fusion protein of CTLA4 and immunoglobulin was constructed (CTLA4-Ig or abatacept and the successor belatacept which differs by only two amino acids) which has a higher affinity to CD28 than B7.
CTLA4 Binding (affinity) of B7 associated with abatacept
2) Confidence 0.11 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2943198 Disease Relevance 0.66 Pain Relevance 0.47
Cytotoxic T-lymphocyte antigen (CTLA4) also interacts with B7 but inhibits T-cell activation.
CTLA4 Binding (interacts) of B7 in T-cell
3) Confidence 0.11 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2943198 Disease Relevance 0.47 Pain Relevance 0.38
Therefore a fusion protein of CTLA4 and immunoglobulin was constructed (CTLA4-Ig or abatacept and the successor belatacept which differs by only two amino acids) which has a higher affinity to CD28 than B7.
CTLA4 Binding (affinity) of B7 associated with abatacept
4) Confidence 0.09 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2943198 Disease Relevance 0.66 Pain Relevance 0.47

General Comments

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