INT2653

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Context Info
Confidence 0.04
First Reported 1979
Last Reported 1996
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 0.37
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc3a1) extracellular region (Penk) plasma membrane (Slc3a1)
carbohydrate metabolic process (Slc3a1)
Anatomy Link Frequency
ACB 1
striatum 1
brain 1
Slc3a1 (Rattus norvegicus)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 15 100.00 Very High Very High Very High
narcan 4 100.00 Very High Very High Very High
Nucleus accumbens 11 98.72 Very High Very High Very High
Eae 4 98.40 Very High Very High Very High
Morphine 3 93.36 High High
opioid receptor 2 83.28 Quite High
dopamine receptor 2 68.08 Quite High
depression 2 67.48 Quite High
addiction 1 63.32 Quite High
antagonist 4 63.04 Quite High
Disease Link Frequency Relevance Heat
Catalepsy 4 94.92 High High
Depression 2 67.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
D1 and D2 receptor regulation of preproenkephalin and preprodynorphin mRNA in rat striatum following acute injection of amphetamine or methamphetamine.
D2 Regulation (regulation) of preproenkephalin in striatum associated with enkephalin
1) Confidence 0.04 Published 1996 Journal Synapse Section Title Doc Link 8787127 Disease Relevance 0 Pain Relevance 0.26
It seemed of interest to study the effect of D-ala2, D-leu5-enkephalin (DADL), when injected into the ACB, on locomotor activity.
D-ala2 Regulation (effect) of D-leu5-enkephalin in ACB associated with nucleus accumbens, eae and enkephalin
2) Confidence 0.03 Published 1983 Journal Life Sci. Section Abstract Doc Link 6363855 Disease Relevance 0.37 Pain Relevance 1.22
Effect of Met-enkephalin and (D-Met2,Pro5)-enkephalinamide on the adenylate cyclase activity of rat brain.
D-Met2 Regulation (Effect) of Met-enkephalin in brain associated with enkephalin
3) Confidence 0.00 Published 1979 Journal Neurochem. Res. Section Title Doc Link 492449 Disease Relevance 0 Pain Relevance 0.48

General Comments

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