INT265311

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 1.57
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Smad2) intracellular (Smad2) protein complex (Smad2)
transcription factor binding (Smad2) cytoplasm (Smad2)
Anatomy Link Frequency
apoptotic cells 2
nucleus 1
Smad2 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 3 91.76 High High
Inflammation 101 78.44 Quite High
cytokine 20 75.20 Quite High
imagery 4 6.88 Low Low
fibrosis 31 5.00 Very Low Very Low Very Low
anesthesia 12 5.00 Very Low Very Low Very Low
ketamine 7 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 87 99.36 Very High Very High Very High
Ganglion Cysts 39 96.32 Very High Very High Very High
Retinal Diseases 6 85.24 High High
Keloid Scars 16 78.88 Quite High
INFLAMMATION 101 78.44 Quite High
Corneal Neovascularization 4 45.04 Quite Low
Cancer 10 25.40 Quite Low
Cytomegalovirus Infection 6 24.88 Low Low
Death 7 20.44 Low Low
Burns 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pattern of apoptotic cells correlated well with the localization of pp-smad2, the direct downstream target of TGF-?
Localization (localization) of smad2 in apoptotic cells associated with apoptosis
1) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.53 Pain Relevance 0.05
We speculate that this might be due to Smad2 import in the nuclei as TSA not only reduces the phosphorylation level of Smad2 but also inhibits its import to the nuclei.
Localization (import) of Smad2
2) Confidence 0.49 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.15 Pain Relevance 0.04
They showed that SB431542 enhanced the effects of BMP-2 on osteogenesis and that this was associated with increased SMAD1 signaling and decreased SMAD2 signaling.
Localization (decreased) of SMAD2
3) Confidence 0.47 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0 Pain Relevance 0
Genes monitored were smad2, smad3, TGF-?
Localization (were) of smad2
4) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.27 Pain Relevance 0
The pattern of apoptotic cells correlated well with the localization of pp-smad2, the direct downstream target of TGF-?
Localization (target) of smad2 in apoptotic cells associated with apoptosis
5) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.54 Pain Relevance 0.05
The phosphorylated Smad2 and Smad3 then form a complex with Smad4 and translocate to the nucleus [29,30].
Localization (translocate) of Smad2 in nucleus
6) Confidence 0.46 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.08 Pain Relevance 0.04
Immunocytochemistry also showed that TSA suppressed nuclear translocation of pSmad2 (Figure 2B).
Localization (translocation) of pSmad2
7) Confidence 0.46 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0 Pain Relevance 0.04
Immunocytochemistry showed that even a low TSA dose (10 nM) suppressed translocation of pSmad2 to the nuclei whereas high doses of TSA (200 and 500 nM) eliminated the pSmad2 signal from the cell nuclei as no pSmad2 expression was detected in the cell nuclei at these 2 TSA doses.
Localization (translocation) of pSmad2
8) Confidence 0.46 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0 Pain Relevance 0

General Comments

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