INT265316

Context Info Confidence 0.35 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0.59 Pain Relevance 0

cell differentiation (Tgfbr1) signal transduction (Tgfbr1) cell motility (Tgfbr1) plasma membrane (Tgfbr1) embryo development (Tgfbr1) protein complex (Tgfbr1)

Tgfbr1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 8 5.00 anesthesia 5 5.00 ketamine 3 5.00 cytokine 2 5.00 dexamethasone 2 5.00 Inflammatory response 2 5.00 imagery 2 5.00 ischemia 1 5.00 Neurotransmitter 1 5.00 Kinase C 1 5.00

Disease Link Frequency Relevance Heat Toxicity 6 97.20 Blister 62 96.16 Infection 10 89.36 Cancer 2 77.84 Immunotherapy Of Cancer 1 74.64 Diabetic Retinopathy 1 68.00 Keloid Scars 36 47.52 Hematological Disease 2 32.88 Parainfluenza Virus Infection 2 21.84 Telangiectasia 4 17.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast to ALK5 signaling, TGF-?

ALK5 Binding (contrast) of

1) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.22 Pain Relevance 0

To explore the interaction or binding of SB-505124 with ALK-5, we docked SB-505124 into the ATP/ligand binding pocket of ALK-5 (Protein data bank access code 1VJY) [45].

ALK-5 Binding (binding) of

2) Confidence 0.07 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956700 Disease Relevance 0.18 Pain Relevance 0

The interaction between SB-505124 and the kinase ALK-5 was investigated using computational docking software.

ALK-5 Binding (interaction) of

3) Confidence 0.06 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956700 Disease Relevance 0.19 Pain Relevance 0

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