INT265317

Context Info Confidence 0.41 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0.90 Pain Relevance 0.06

transport (Smad3) intracellular (Smad3) DNA binding (Smad3) protein complex (Smad3) cytoplasm (Smad3) nucleus (Smad3)

Anatomy Link Frequency chondrocytes 2 articular 2 Smad3 (Mus musculus)

Pain Link Frequency Relevance Heat Osteoarthritis 182 61.60 Kinase C 1 25.64 cytokine 10 5.00 metalloproteinase 6 5.00 fibrosis 4 5.00 Inflammation 2 5.00 Pain 2 5.00 Arthritis 2 5.00 ketamine 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Hypertrophy 10 97.64 Targeted Disruption 2 95.32 Retinal Diseases 2 85.88 Ganglion Cysts 13 68.24 Osteoarthritis 192 61.60 Disease 24 54.12 Apoptosis 31 48.72 Aging 26 42.44 Cytomegalovirus Infection 2 25.44 Fibrosis 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In articular chondrocytes treated with azacytidine, reduced Smad2 and Smad3 expression and signaling and increased Smad1/5 expression correlated with elevated synthesis of type X collagen and alkaline phosphatase.

Negative_regulation (reduced) of Gene_expression (expression) of Smad3 in articular

1) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.44 Pain Relevance 0.03

Overexpression of both Smad2 and Smad3 blocked spontaneous maturation in Smad3-deficient chondrocytes [70,71].

Negative_regulation (blocked) of Gene_expression (Overexpression) of Smad3 in chondrocytes

2) Confidence 0.30 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.19 Pain Relevance 0.03

Genes monitored were smad2, smad3, TGF-?

Negative_regulation (monitored) of Gene_expression (Genes) of smad3

3) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.27 Pain Relevance 0

General Comments

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