INT265318

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Context Info
Confidence 0.26
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.16
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Smad2) intracellular (Smad2) protein complex (Smad2)
transcription factor binding (Smad2) cytoplasm (Smad2)
Anatomy Link Frequency
chondrocytes 2
articular 2
F4/80 2
Smad2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 75 98.88 Very High Very High Very High
fibrosis 101 98.08 Very High Very High Very High
Inflammation 55 89.92 High High
antagonist 12 86.52 High High
Osteoarthritis 182 61.60 Quite High
Kinase C 1 25.64 Quite Low
cytokine 18 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 110 98.08 Very High Very High Very High
Hypertrophy 10 97.64 Very High Very High Very High
Sclerosis 8 96.28 Very High Very High Very High
Targeted Disruption 2 95.32 Very High Very High Very High
INFLAMMATION 59 89.92 High High
Ureteral Obstruction 48 89.00 High High
Retinal Diseases 2 85.88 High High
Ganglion Cysts 13 68.24 Quite High
Osteoarthritis 192 61.60 Quite High
Chronic Renal Failure 6 54.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genes monitored were smad2, smad3, TGF-?
Negative_regulation (monitored) of Gene_expression (Genes) of smad2
1) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.27 Pain Relevance 0
Western blot analysis of samples treated with 200 nM TSA did not completely block phosphorylation of Smad2; instead, it faintly reduced the pSmad2 levels at 2 h post-TGF?
Negative_regulation (reduced) of Gene_expression (levels) of pSmad2
2) Confidence 0.24 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.05 Pain Relevance 0
BMP-2 increased pSMAD1 levels, and also reduced pSMAD2 levels.
Negative_regulation (reduced) of Gene_expression (levels) of pSMAD2
3) Confidence 0.23 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0.12 Pain Relevance 0.03
In articular chondrocytes treated with azacytidine, reduced Smad2 and Smad3 expression and signaling and increased Smad1/5 expression correlated with elevated synthesis of type X collagen and alkaline phosphatase.
Negative_regulation (reduced) of Gene_expression (expression) of Smad2 in articular
4) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.44 Pain Relevance 0.03
Overexpression of both Smad2 and Smad3 blocked spontaneous maturation in Smad3-deficient chondrocytes [70,71].
Negative_regulation (blocked) of Gene_expression (Overexpression) of Smad2 in chondrocytes
5) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.19 Pain Relevance 0.03
In the all of treated groups (pioglitazone treated group, L158809 treated group, combined treatment group), the p-Smad2 expressions were decreased compared to CONT (Fig. 5).
Negative_regulation (decreased) of Gene_expression (expressions) of Smad2
6) Confidence 0.20 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2799997 Disease Relevance 0.09 Pain Relevance 0.04
The immunohistochmistry of PAI-1, F4/80 and p-Smad2 demonstrated that their expressions were increased in CONT group and decreased in the all treated groups compared to CONT.
Negative_regulation (decreased) of Gene_expression (expressions) of Smad2 in F4/80
7) Confidence 0.19 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2799997 Disease Relevance 0.66 Pain Relevance 0.39
Our findings showed that the p-Smad2 expression was also decreased in the PPAR?
Negative_regulation (decreased) of Gene_expression (expression) of Smad2
8) Confidence 0.19 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2799997 Disease Relevance 0.35 Pain Relevance 0.19

General Comments

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