INT265322

Context Info Confidence 0.23 First Reported 2009 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.30 Pain Relevance 0

cytosol (Ocln) structural molecule activity (Ocln) plasma membrane (Ocln)

Ocln (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 3 5.00 anesthesia 3 5.00 ketamine 2 5.00 ischemia 2 5.00 Neurotransmitter 2 5.00 Kinase C 2 5.00 isoflurane 2 5.00 imagery 2 5.00 Neurobehavioral 1 5.00 Inflammatory mediators 1 5.00

Disease Link Frequency Relevance Heat Cancer 25 88.96 Congenital Anomalies 4 82.44 Diabetic Angiopathy 2 73.80 Ganglion Cysts 26 53.92 Metastasis 25 50.00 Apoptosis 58 43.20 Reprotox - General 3 2 32.40 Melanoma 12 18.96 Death 4 18.12 Telangiectasia 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Immunoprecipitation of occludin followed by western blotting for zo-1 revealed that coculture of EC with 10T1/2 cells led to an increased association between occludin and zo-1 in EC, which was significantly reduced by TGF-?

Positive_regulation (increased) of occludin Binding (association) of

1) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.05 Pain Relevance 0

In concordance with these observations in vivo, coculture of ECs and 10T1/2 cells led to enhanced EC barrier function, and the addition of the ALK5 inhibitor reversed this effect and reduced coculture-induced association between occludin and zo-1.

Positive_regulation (induced) of occludin Binding (association) of

2) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.25 Pain Relevance 0

The enhanced interaction between ZO-1 and occludin appeared to be most pronounced in cerebral microvessels of PCB126-treated animals, followed by the PCB153 treatment group.

Positive_regulation (enhanced) of occludin Spec (appeared) Binding (interaction) of

3) Confidence 0.07 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854723 Disease Relevance 0 Pain Relevance 0

General Comments

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