INT265325

Context Info Confidence 0.18 First Reported 2009 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.07 Pain Relevance 0

cytosol (Ocln) structural molecule activity (Ocln) plasma membrane (Ocln)

Anatomy Link Frequency retinas 1 Ocln (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 1 28.56 Central nervous system 3 5.00 anesthesia 2 5.00 imagery 2 5.00 ketamine 1 5.00 ischemia 1 5.00 Neurotransmitter 1 5.00 Neurobehavioral 1 5.00 Inflammatory mediators 1 5.00 metalloproteinase 1 5.00

Disease Link Frequency Relevance Heat Cancer 23 72.76 Metastasis 25 50.00 Congenital Anomalies 2 48.04 Diabetic Angiopathy 1 39.40 Apoptosis 29 21.28 Ganglion Cysts 13 18.80 Melanoma 12 5.00 Brain Tumor 6 5.00 Telangiectasia 4 5.00 Pre-eclampsia 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

While there was no change in the levels of the tight junction proteins zo-1 and occludin in retinas from sEng-expressing mice (data not shown), there was a decrease in association between these proteins, a characteristic feature of tight junction disassembly [28].

Neg (no) Regulation (change) of occludin in retinas

1) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.07 Pain Relevance 0

Therefore, we examined the effects of PCB treatment on the localization profiles of claudin-5, occludin, and ZO-1 in freshly isolated microvessels (Figures 2 and 3).

Spec (examined) Regulation (effects) of occludin

2) Confidence 0.06 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854723 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.