INT265326

Context Info Confidence 0.43 First Reported 2009 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0.17 Pain Relevance 0

cell differentiation (Tgfbr1) signal transduction (Tgfbr1) cell motility (Tgfbr1) plasma membrane (Tgfbr1) embryo development (Tgfbr1) protein complex (Tgfbr1)

Tgfbr1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 2 5.00 palliative 1 5.00 ketamine 1 5.00 fibrosis 1 5.00 anesthesia 1 5.00 ischemia 1 5.00 Neurotransmitter 1 5.00 metalloproteinase 1 5.00 Kinase C 1 5.00 Immobilon 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 50 89.20 Volume Depletion And Dehydration 1 39.00 Infection 2 25.04 Leukemia 5 24.24 Cancer 94 5.00 Aging 24 5.00 Metastasis 15 5.00 Syndrome 14 5.00 Ganglion Cysts 13 5.00 Injury 8 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To examine effects of ALK5 inhibition, 10 µM SB-431542 was added for 72 hr in DMEM containing 1% FBS.

Spec (examine) Regulation (effects) of ALK5

1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.17 Pain Relevance 0

ALK5 signaling was inhibited by adding SB431542 at 10 µM in the medium 2 days after embedding of rings in collagen gels.

Regulation (signaling) of ALK5

2) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0 Pain Relevance 0

Shao et al. demonstrated that ALK-1 and ALK-5 are both essential for the regulation of vascular endothelial growth factor (VEGF), which is believed to be the central growth factor in angiogenesis.

Regulation (regulation) of ALK-5

3) Confidence 0.02 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 0 Pain Relevance 0

General Comments

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