INT26534

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Context Info
Confidence 0.61
First Reported 1989
Last Reported 2010
Negated 2
Speculated 9
Reported most in Body
Documents 34
Total Number 42
Disease Relevance 14.47
Pain Relevance 11.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt1) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1)
Anatomy Link Frequency
muscle 5
skeletal muscle 2
neurons 2
PC-12 1
ileum 1
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 10 99.84 Very High Very High Very High
narcan 1 99.80 Very High Very High Very High
antagonist 131 99.60 Very High Very High Very High
Morphine 40 99.32 Very High Very High Very High
agonist 157 99.24 Very High Very High Very High
Nucleus accumbens 14 99.24 Very High Very High Very High
Dopamine 482 99.06 Very High Very High Very High
antidepressant 15 98.92 Very High Very High Very High
ischemia 195 98.82 Very High Very High Very High
opioid receptor 137 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aging 342 99.98 Very High Very High Very High
Neuropathic Pain 10 99.84 Very High Very High Very High
Sepsis 66 99.64 Very High Very High Very High
Cv Unclassified Under Development 67 98.82 Very High Very High Very High
Pain 21 98.60 Very High Very High Very High
Cv General 4 Under Development 121 98.32 Very High Very High Very High
Depression 18 98.02 Very High Very High Very High
Apoptosis 128 97.72 Very High Very High Very High
Stress 42 97.40 Very High Very High Very High
Neointima 11 96.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we investigated the effect of prenatal stress (an animal model of depression) and long-term treatment with antidepressant drugs on the concentration of GSK-3beta and its main regulating protein kinase B (PKB, Akt).
Regulation (regulating) of PKB associated with stress, antidepressant and depression
1) Confidence 0.61 Published 2009 Journal Pharmacol Rep Section Abstract Doc Link 19815943 Disease Relevance 0.65 Pain Relevance 0.37
As a key molecule promoting anabolism and cellular survival, it is likely that age-associated Akt dysregulation may directly contribute to the deterioration of cellular metabolism and physiological function.
Regulation (dysregulation) of Akt
2) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.31 Pain Relevance 0.09
Although alterations in Akt abundance and phosphorylation have been shown in aging muscle [5], [6], little is known about whether or not aging affects Akt kinase function.
Spec (whether) Regulation (affects) of Akt kinase in muscle associated with aging
3) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.65 Pain Relevance 0.04
Whether age-related alterations in the amount or regulation of these factors affect Akt function in aging skeletal muscle is not known.
Spec (Whether) Regulation (affect) of Akt in skeletal muscle associated with aging
4) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.68 Pain Relevance 0.11
We investigated the potential modulation of Akt and MAPK signaling activity.
Spec (investigated) Regulation (modulation) of Akt
5) Confidence 0.49 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
The present study examined the regulation of ERK and Akt activation in the nucleus accumbens and caudate putamen following acute and chronic morphine administration in the rat.
Spec (examined) Regulation (regulation) of Akt in caudate putamen associated with nucleus accumbens and morphine
6) Confidence 0.45 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15056728 Disease Relevance 0 Pain Relevance 0.53
Whereas the inhibitory effect of Akt inhibitor IV on established neuropathic pain was observed only in those rats that received the drug treatment started at the 1st day.
Regulation (effect) of Akt associated with neuropathic pain
7) Confidence 0.44 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17628541 Disease Relevance 0.72 Pain Relevance 1.06
Further, we demonstrate that acetaminophen administration functions to prevent age-associated Akt hyper-phosphorylation and dysfunction in aging muscle by decreasing S-nitrosylated Akt and restoring PTEN protein levels.
Regulation (nitrosylated) of Akt in muscle associated with paracetamol and aging
8) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.49 Pain Relevance 0.22
Akt function is controlled, at least in part, by the phosphorylation of Ser473 by the mammalian target of rapamycin (mTOR) and the phosphorylation of Thr308 by phosphoinositide-dependent kinase (PDK)-1 [10]–[12].
Regulation (controlled) of Akt
9) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.65 Pain Relevance 0.04
It has been demonstrated that reactive oxygen species (ROS) and signaling molecules, such as the serine/threonine protein kinase Akt, are involved in neuropathic pain mechanisms.
Regulation (involved) of Akt associated with neuropathic pain
10) Confidence 0.43 Published 2008 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 18379870 Disease Relevance 0.53 Pain Relevance 0.66
Although alterations in Akt abundance and phosphorylation have been shown in aging muscle [5], [6], little is known about whether or not aging affects Akt kinase function.
Regulation (alterations) of Akt in muscle associated with aging
11) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.63 Pain Relevance 0.09
Furthermore, to explore if the cardioprotective properties mediated by the coronary IPC effluent were dependent on PI3K/Akt-dependent signaling at reperfusion, the PI3K-inhibitor Wortmannin (WI; 1 ?
Regulation (dependent) of Akt
12) Confidence 0.36 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC3012213 Disease Relevance 0.31 Pain Relevance 0.16
Nevertheless, our results suggest, first, that cAMP is probably involved in the regulation of Akt in hippocampal neurons in a manner that is different from that observed in striatal neurons (Fig. 8C) and, second, that cAMP likely plays a role in the regulation of mitochondrial movement (Fig. 9A).
Regulation (regulation) of Akt in neurons
13) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2467486 Disease Relevance 0 Pain Relevance 0.13
These data suggest that OIC occurs via the JAK2 regulation of PI3K pathway-dependent STAT3, Akt, and GSK-3 beta, with GSK-3 beta contributing a central role in acute OIC.
Regulation (regulation) of Akt
14) Confidence 0.29 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16517948 Disease Relevance 0.13 Pain Relevance 0.41
In the present study, we investigated the effect of prenatal stress (an animal model of depression) and long-term treatment with antidepressant drugs on the concentration of GSK-3beta and its main regulating protein kinase B (PKB, Akt).
Regulation (regulating) of Akt associated with stress, antidepressant and depression
15) Confidence 0.27 Published 2009 Journal Pharmacol Rep Section Abstract Doc Link 19815943 Disease Relevance 0.65 Pain Relevance 0.38
The mechanism through which H2S targets the PI3K/AKT pathway involves KATP channels.
Regulation (targets) of AKT
16) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.38
Protein kinase B (PKB/Akt) is a member of the second-messenger regulated subfamily of protein kinases.
Regulation (regulated) of Akt
17) Confidence 0.26 Published 2007 Journal Neuroscience Section Abstract Doc Link 17084039 Disease Relevance 0.36 Pain Relevance 0.42
Protein kinase B (Akt/PKB) is an important regulator of cellular metabolism and survival, but it is unclear if aged muscle exhibits alterations in Akt function.
Regulation (regulator) of Akt in muscle
18) Confidence 0.26 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2712760 Disease Relevance 0.26 Pain Relevance 0.16
Protein kinase B (Akt/PKB) is an important regulator of cellular metabolism and survival, but it is unclear if aged muscle exhibits alterations in Akt function.
Regulation (regulator) of Protein kinase B in muscle
19) Confidence 0.26 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2712760 Disease Relevance 0.26 Pain Relevance 0.16
The purpose of this study was to examine if aging-related changes in skeletal muscle structure are associated with alterations in Akt function.
Regulation (alterations) of Akt in skeletal muscle associated with aging
20) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.86 Pain Relevance 0.09

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