INT265341

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Context Info
Confidence 0.13
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.22
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
vessels 2
ecs (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 19 93.44 High High
Bioavailability 2 72.40 Quite High
Inflammation 18 69.16 Quite High
cytokine 13 18.04 Low Low
chemokine 2 17.64 Low Low
Central nervous system 14 5.00 Very Low Very Low Very Low
Hippocampus 10 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
diabetic neuropathy 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 35 99.90 Very High Very High Very High
Reprotox - General 3 1 90.92 High High
Increased Venous Pressure Under Development 20 80.88 Quite High
Ganglion Cysts 14 80.72 Quite High
Atherosclerosis 2 73.60 Quite High
INFLAMMATION 20 69.16 Quite High
Chronic Disease 1 61.44 Quite High
Congenital Anomalies 8 59.80 Quite High
Diabetes Mellitus 50 59.28 Quite High
Adhesions 6 51.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nuclear condensation associated with apoptosis was apparent in some, but not all pericytes (Figure 7C) and ECs (Figure D), and, consistent with our findings of non-perfusion and impaired NO formation in sEng expressing mice, many vessels appeared completely or partially collapsed (Figures 7E and 7F).


Negative_regulation (apparent) of Gene_expression (expressing) of ECs in vessels associated with apoptosis
1) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.51 Pain Relevance 0
Thus, the production of NO in ECs is inhibited.
Negative_regulation (inhibited) of Gene_expression (production) of ECs
2) Confidence 0.05 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.72 Pain Relevance 0.22

General Comments

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