INT265346

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 1.11
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ocln, Tjp1) cytosol (Ocln) Golgi apparatus (Tjp1)
structural molecule activity (Ocln) nucleus (Tjp1) cytoplasm (Tjp1)
Anatomy Link Frequency
tail 1
Fundus 1
Ocln (Mus musculus)
Tjp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 6 91.36 High High
agonist 4 87.84 High High
Inflammatory mediators 4 47.12 Quite Low
Central nervous system 12 27.52 Quite Low
Neurobehavioral 4 10.92 Low Low
anesthesia 10 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 12 95.48 Very High Very High Very High
Cancer 96 89.68 High High
Diabetic Angiopathy 6 86.84 High High
Apoptosis 174 84.56 Quite High
Death 12 84.16 Quite High
Ganglion Cysts 78 72.96 Quite High
Metastasis 100 50.00 Quite Low
Breast Cancer 4 49.72 Quite Low
Cytomegalovirus Infection 12 49.04 Quite Low
Adhesions 8 47.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, binding of zo-1 to the COOH-terminal cytoplasmic tail of occludin plays a role in maintaining the tight junction and also cytoskeletal tethering [48], whereas previous studies describe the association of occludin/zo-1 as dependent upon both tyrosine phosphatase signaling and also protein kinase C [49].
occludin Binding (binding) of zo-1 in tail associated with kinase c
1) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.27 Pain Relevance 0.05
In concordance with these observations in vivo, coculture of ECs and 10T1/2 cells led to enhanced EC barrier function, and the addition of the ALK5 inhibitor reversed this effect and reduced coculture-induced association between occludin and zo-1.
occludin Binding (association) of zo-1
2) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.25 Pain Relevance 0
Immunoprecipitation of occludin followed by western blotting for zo-1 revealed that coculture of EC with 10T1/2 cells led to an increased association between occludin and zo-1 in EC, which was significantly reduced by TGF-?
occludin Binding (association) of zo-1
3) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.05 Pain Relevance 0
Results of fluorescein angiography, Evans blue extravasation, and western blotting for association of the tight junction proteins occludin and zo-1 suggest that endogenous TGF-?
occludin Binding (association) of zo-1
4) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.30 Pain Relevance 0
Changes in occludin/zo-1 co-association were monitored by immunoprecipitation, performed as previously described [53] with minor modifications.
occludin Binding (association) of zo-1
5) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0 Pain Relevance 0
Fundus angiography and Evans blue permeability assay revealed a breakdown of the blood-retinal-barrier that was characterized by decreased association between the tight junction proteins zo-1 and occludin.
occludin Binding (association) of zo-1 in Fundus
6) Confidence 0.03 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2659748 Disease Relevance 0.17 Pain Relevance 0
Because occludin interacts with ZO-1 at its C-terminus, we next determined the effects of individual PCB congeners on colocalization staining patterns for these proteins.
occludin Spec (determined) Binding (interacts) of ZO-1
7) Confidence 0.01 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854723 Disease Relevance 0 Pain Relevance 0
Confocal microscopy suggests that PCB treatment can enhance the association between ZO-1 and occludin, as shown in yellow in the merged and phase-contrast micrographs in Figure 3 (arrows).
occludin Binding (association) of ZO-1
8) Confidence 0.01 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854723 Disease Relevance 0 Pain Relevance 0
Exposure to PCB118 and PCB153 modulated expressional levels of claudin-5 and ZO-1, whereas PCB126 appeared to primarily influence the coassociation of occludin and ZO-1.
occludin Spec (appeared) Binding (coassociation) of ZO-1
9) Confidence 0.01 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854723 Disease Relevance 0.06 Pain Relevance 0.04
The enhanced interaction between ZO-1 and occludin appeared to be most pronounced in cerebral microvessels of PCB126-treated animals, followed by the PCB153 treatment group.


occludin Spec (appeared) Binding (interaction) of ZO-1
10) Confidence 0.01 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854723 Disease Relevance 0 Pain Relevance 0

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