INT265376

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Context Info
Confidence 0.51
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.80
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hdac3) DNA binding (Hdac3) cytoplasm (Hdac3)
Anatomy Link Frequency
lung 1
Hdac3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 57 83.72 Quite High
Inflammatory response 24 64.88 Quite High
tolerance 2 53.12 Quite High
Eae 2 21.16 Low Low
depression 9 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
antiepileptic Drug 7 5.00 Very Low Very Low Very Low
Lamotrigine 6 5.00 Very Low Very Low Very Low
gABA 6 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Obstructive Pulmonary Disease 108 100.00 Very High Very High Very High
Adhesions 1 98.88 Very High Very High Very High
Disease 67 98.32 Very High Very High Very High
Targeted Disruption 4 89.92 High High
Synovial Sarcoma 35 89.48 High High
INFLAMMATION 84 83.72 Quite High
Cancer 36 77.84 Quite High
Repression 6 69.12 Quite High
Leukemia 9 66.88 Quite High
Thyroid Neoplasm 3 58.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is consistent with the established corepressor function of NcoR1/Hdac3 for Rev-erb?
Gene_expression (/) of Hdac3
1) Confidence 0.51 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.16 Pain Relevance 0
Furthermore, HDAC3 knockdown
Gene_expression (knockdown) of HDAC3
2) Confidence 0.41 Published 2009 Journal Sarcoma Section Body Doc Link PMC2659882 Disease Relevance 0.25 Pain Relevance 0
HDAC3 is one of the direct targets of VPA, but until now no papers present data concerning the effect of VPA on the STAT3 pathway.

4.

Gene_expression (one) of HDAC3
3) Confidence 0.19 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.53 Pain Relevance 0.03
In addition, as there is a reduction in expression of other HDACs in COPD, including HDAC-3, 5, and 8, it must also be considered that the alteration in the expression and/or activity of other HDACs may also play a role in the impairment of GC function.86 Cigarette smoke exposure results in a reduction of HDAC-1, 2, and 3 in the macrophage cell line, Mono Mac 6 cells, associated with elevated tyrosine nitration and aldehyde adduct formation.88 However, the roles of these HDACs in the lung and inflammatory cells involved in COPD are poorly understood, and studies are needed to clarify their roles in GR function and in disease.


Gene_expression (expression) of HDAC-3 in lung associated with inflammation, chronic obstructive pulmonary disease and disease
4) Confidence 0.06 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.86 Pain Relevance 0.10

General Comments

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