INT26538

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Context Info
Confidence 0.69
First Reported 1980
Last Reported 2010
Negated 7
Speculated 0
Reported most in Abstract
Documents 103
Total Number 103
Disease Relevance 30.95
Pain Relevance 15.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FSHR) plasma membrane (FSHR) signal transducer activity (FSHR)
Anatomy Link Frequency
follicle 34
plasma 8
pituitary 2
liver 1
14.1 1
FSHR (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 118 100.00 Very High Very High Very High
alcohol 106 100.00 Very High Very High Very High
antagonist 288 99.74 Very High Very High Very High
Opioid 29 99.52 Very High Very High Very High
imagery 22 99.16 Very High Very High Very High
Pain 126 99.08 Very High Very High Very High
Fibrositis 169 98.84 Very High Very High Very High
cytokine 8 98.16 Very High Very High Very High
Analgesic 4 97.96 Very High Very High Very High
agonist 333 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypogonadotropic Hypogonadism 200 99.92 Very High Very High Very High
Polycystic Ovary Syndrome 227 99.72 Very High Very High Very High
Endometriosis (extended) 468 99.64 Very High Very High Very High
Male Infertility 96 99.58 Very High Very High Very High
Sperm Disorder 6 99.58 Very High Very High Very High
Gynecomastia 27 99.34 Very High Very High Very High
Anovulation 108 99.32 Very High Very High Very High
Fibromyalgia 169 98.84 Very High Very High Very High
Nicotine Addiction 20 98.84 Very High Very High Very High
Reprotox - General 1 233 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In general, the plasma FSH levels could be divided into 3 phases: 0-24 hours, 24-72 hours, and 72-360 hours, with higher elevated FSH concentrations in 0-24 hours in women receiving vaginal injections compared to those in women receiving abdominal injections, while in the 24-72 hours period a similar curve of FSH levels were produced in both groups with higher FSH concentrations in women receiving abdominal injections (Figure 1 and figure 2).
Positive_regulation (elevated) of FSH in plasma
1) Confidence 0.69 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0.36 Pain Relevance 0.17
This pattern was lost in castrate and post-menopausal monkeys in which FSH levels were significantly increased (P<0.0001) above those of intact males and young females, respectively.
Positive_regulation (increased) of FSH associated with endometriosis (extended)
2) Confidence 0.68 Published 1999 Journal Am. J. Primatol. Section Abstract Doc Link 10333433 Disease Relevance 0.30 Pain Relevance 0.07
The other trial, comparing follitropin beta and HP uFSH, also found a significantly lower requirement of FSH when using follitropin beta (Puregon) though there was no indication for a difference in duration of stimulation (mean 10.2 days versus 9.8 days).31 The total costs per cycle however were significantly higher for a follitropin beta cycle due to the lower costs per IU of HP uFSH.
Positive_regulation (requirement) of FSH
3) Confidence 0.63 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971716 Disease Relevance 0.11 Pain Relevance 0
The cost and effects of follitropin alpha and beta were compared with HP uFSH in 2 randomized controlled trials.29,31 The trial comparing follitropin alpha with HP uFSH revealed a significantly lower requirement of FSH when using follitropin alpha (Gonal-F), with mean doses of 844 IU and 668 IU per cycle respectively.29 The total costs however were higher for follitropin alpha though this difference was not statistically significant (mean cost per cycle of €208 for Gonal F versus €175 for HP uFSH).
Positive_regulation (requirement) of FSH
4) Confidence 0.63 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971716 Disease Relevance 0.34 Pain Relevance 0.13
In the male subjects, naloxone at a dose of 25 micrograms/kg caused a significant increase in serum LH and FSH; no increase in response was seen at the two higher doses (100 micrograms/kg and 250 micrograms/kg).
Positive_regulation (increase) of FSH associated with narcan
5) Confidence 0.63 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3008020 Disease Relevance 0 Pain Relevance 0.40
(Note that girls can have elevated FSH levels up to 4 years of age.)
Positive_regulation (elevated) of FSH
6) Confidence 0.57 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2453165 Disease Relevance 0 Pain Relevance 0
In order to assess the efficacy and safety of recombinant human follicle stimulating hormone (FSH) in routine clinical use, ovarian stimulation with recombinant human FSH was performed in 71 patients prior to in-vitro fertilization (IVF) without gonadotrophin-releasing hormone (GnRH) analogues in a multicentre, non-comparative study.
Positive_regulation (stimulation) of FSH in follicle
7) Confidence 0.50 Published 1995 Journal Hum. Reprod. Section Abstract Doc Link 8822421 Disease Relevance 0 Pain Relevance 0
For this purpose, the capability of the opioid antagonist naloxone to increase circulating levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and cortisol was tested in male subjects of different ages.
Positive_regulation (increase) of FSH in follicle associated with antagonist, narcan and opioid
8) Confidence 0.48 Published 1989 Journal Horm. Res. Section Abstract Doc Link 2560454 Disease Relevance 0.17 Pain Relevance 0.40
For this purpose, the capability of the opioid antagonist naloxone to increase circulating levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and cortisol was tested in male subjects of different ages.
Positive_regulation (increase) of follicle-stimulating hormone in follicle associated with antagonist, narcan and opioid
9) Confidence 0.48 Published 1989 Journal Horm. Res. Section Abstract Doc Link 2560454 Disease Relevance 0.17 Pain Relevance 0.40
The present data form part of the clinical development program describing the comparative efficacy and safety of Bravelle®, the newest approved, highly purified (96–98%), human-derived FSH which contains ?
Positive_regulation (derived) of FSH
10) Confidence 0.48 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC270000 Disease Relevance 0 Pain Relevance 0
FSH levels fell to baseline values with repeated injections, whereas luteinizing hormone levels remained elevated in all patients.
Positive_regulation (elevated) of FSH
11) Confidence 0.48 Published 1985 Journal Fertil. Steril. Section Abstract Doc Link 3932097 Disease Relevance 0.63 Pain Relevance 0.15
Serum testosterone remained undetectable less than 1.0 nmol/l, the hyporesponsiveness of serum LH was not improved, but basal FSH level was significantly increased and the impaired FSH response to the standard GnRH test was slightly improved.
Positive_regulation (increased) of FSH
12) Confidence 0.46 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 3101337 Disease Relevance 0.14 Pain Relevance 0.16
The ability of FSH to promote folliculogenesis is dependent on the plasma level of FSH that develops after administration [1-3].
Positive_regulation (dependent) of FSH in plasma
13) Confidence 0.46 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0
Follicle stimulating hormone (FSH) has been routinely used for ovulation induction.
Positive_regulation (induction) of Follicle stimulating hormone in Follicle
14) Confidence 0.46 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0
Follicle stimulating hormone (FSH) has been routinely used for ovulation induction.
Positive_regulation (induction) of FSH in Follicle
15) Confidence 0.46 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0
Mukherjee et al. [13] suggested that an elevated day 3 FSH: LH ratio >3.6, in the presence of a normal day 3 FSH is predictive of a poor response to ovarian stimulation.
Positive_regulation (elevated) of FSH
16) Confidence 0.44 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1947995 Disease Relevance 0.15 Pain Relevance 0.14
When the daily dose of methadone was decreased to 40 mg, the patient's libido returned, and LH, FSH, and testosterone levels increased.
Positive_regulation (increased) of FSH
17) Confidence 0.44 Published 1996 Journal Endocr Pract Section Body Doc Link 15251556 Disease Relevance 0.07 Pain Relevance 0
FSH pulses were not discernible in individual subjects; however, a significant increment in FSH levels occurred concomitantly with the increase in LH.
Positive_regulation (increment) of FSH
18) Confidence 0.44 Published 1981 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6780598 Disease Relevance 0 Pain Relevance 0.42
Ovarian stimulation in women undergoing in-vitro fertilization and embryo transfer using recombinant human follicle stimulating hormone (Gonal-F) in non-down-regulated cycles.
Positive_regulation (using) of stimulating hormone in follicle
19) Confidence 0.44 Published 1995 Journal Hum. Reprod. Section Title Doc Link 8822421 Disease Relevance 0.10 Pain Relevance 0.08
FSH is derived from urine or is produced as recombinant FSH.
Positive_regulation (derived) of FSH in urine
20) Confidence 0.42 Published 2010 Journal International Journal of Women's Health Section Abstract Doc Link PMC2971716 Disease Relevance 0.27 Pain Relevance 0

General Comments

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