INT265417

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Context Info
Confidence 0.16
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.10
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TLR3) signal transduction (TLR3) endoplasmic reticulum (TLR3)
intracellular (TLR3) cytoplasm (TLR3)
Anatomy Link Frequency
poly 2
TLR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 44.88 Quite Low
chemokine 19 32.68 Quite Low
agonist 6 32.56 Quite Low
Potency 18 5.00 Very Low Very Low Very Low
cytokine 14 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Age-related Macular Degeneration 14 100.00 Very High Very High Very High
Toxicity 9 98.56 Very High Very High Very High
Body Weight 4 74.72 Quite High
Myeloid Leukemia 2 74.32 Quite High
Congenital Anomalies 2 72.40 Quite High
Immunization 21 68.68 Quite High
Hyperlipidemia 2 61.60 Quite High
Papillomavirus Infection 18 50.00 Quite Low
Pachyonychia Congenita 2 49.76 Quite Low
Asthma 2 45.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The poly I:C analogue poly I:C12U requires TLR3 to be active in vivo [54],[55] and shows little toxicity in humans [48].
Positive_regulation (requires) of Positive_regulation (active) of TLR3 in poly associated with toxicity
1) Confidence 0.16 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.30 Pain Relevance 0
Despite this limitation, and a report that its efficacy might be mediated via TLR-3 activation [14], 330 patients were enrolled in a phase III trial to study the safety and efficacy of bevasiranib in wet AMD [73].
Positive_regulation (mediated) of Positive_regulation (activation) of TLR-3 associated with age-related macular degeneration
2) Confidence 0.07 Published 2010 Journal Silence Section Body Doc Link PMC2908561 Disease Relevance 0.38 Pain Relevance 0
AGN211745 too was shown to be possibly mediating its effects in preclinical models of AMD via TLR-3 activation [14].
Spec (possibly) Positive_regulation (mediating) of Positive_regulation (activation) of TLR-3 associated with age-related macular degeneration
3) Confidence 0.06 Published 2010 Journal Silence Section Body Doc Link PMC2908561 Disease Relevance 0.41 Pain Relevance 0

General Comments

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