INT265418

Context Info Confidence 0.20 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.32 Pain Relevance 0.22

extracellular space (CCL21) extracellular region (CCL21) cell-cell signaling (CCL21)

Anatomy Link Frequency lymph nodes 2 CCL21 (Homo sapiens)

Pain Link Frequency Relevance Heat chemokine 15 100.00 cytokine 8 96.68 Inflammation 4 96.28 ketamine 2 5.00 agonist 2 5.00 anesthesia 1 5.00 Inflammatory response 1 5.00 Bioavailability 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 5 96.28 Papillomavirus Infection 18 88.16 Immunization 15 5.00 Infection 8 5.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 4 5.00 Mycobacterial Infection 4 5.00 Body Weight 4 5.00 Toxicity 3 5.00 Cervical Cancer 2 5.00 Malaria 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

After injection of dsRNA, we observed a down-regulation of the homeostatic chemokine CCL21, which attracts CCR7+ cells, such as DCs and naïve T cells, to lymph nodes.

Negative_regulation (down) of Negative_regulation (regulation) of homeostatic chemokine CCL21 in lymph nodes associated with chemokine

1) Confidence 0.20 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.32 Pain Relevance 0.22

General Comments

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