INT265433

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Context Info
Confidence 0.64
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 3.76
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Sprr1b) protein binding, bridging (Sprr1b) cytoplasm (Sprr1b)
Anatomy Link Frequency
goblet cell 2
immune cell 1
cornea 1
corneal epithelium 1
T lymphocytes 1
Sprr1b (Mus musculus)
Pain Link Frequency Relevance Heat
Sicca syndrome 126 97.28 Very High Very High Very High
Inflammation 174 95.12 Very High Very High Very High
tolerance 18 83.48 Quite High
addiction 6 54.80 Quite High
cytokine 6 5.00 Very Low Very Low Very Low
Thoracotomy 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metaplasia 132 99.96 Very High Very High Very High
Hyperplasia 6 99.92 Very High Very High Very High
Syndrome 132 97.28 Very High Very High Very High
Severe Combined Immunodeficiency 12 95.24 Very High Very High Very High
INFLAMMATION 174 95.12 Very High Very High Very High
Disease 66 91.76 High High
Disorders Of The Lacrimal System 222 90.04 High High
Autoimmune Disease 36 86.60 High High
Dry Eye 12 76.92 Quite High
Eye Disease 66 67.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased SPRR1B was observed in impression cytology samples of human patients with SS, in Aire-deficient mice, and in Aire-sufficient severe combined immunodeficiency (SCID) mice following adoptive transfer of Aire-deficient CD4+ T lymphocytes [15].
Positive_regulation (Increased) of SPRR1B in T lymphocytes associated with sicca syndrome and severe combined immunodeficiency
1) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 1.34 Pain Relevance 0.31
Increased levels of corneal SPRR1B persisted to 16 weeks while the corneal epithelium progressed to metaplasia.
Positive_regulation (Increased) of SPRR1B in corneal epithelium associated with metaplasia
2) Confidence 0.56 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.30 Pain Relevance 0
Interestingly, the presence of resident DCs in the limbus and activated DCs in the central cornea were the strongest predictors of squamous metaplasia, using SPRR1B as a biomarker.
Positive_regulation (using) of SPRR1B in cornea associated with metaplasia
3) Confidence 0.40 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.97 Pain Relevance 0.05
Together, goblet cell drop out and increased corneal SPRR1B indicate the presence of ocular surface keratinization by eight weeks in Aire-deficient mice, and these changes persist with age.
Positive_regulation (increased) of SPRR1B in goblet cell
4) Confidence 0.38 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.44 Pain Relevance 0.03
Compared to Aire-sufficient controls, conjunctival goblet cell density (GCD) decreased and corneal SPRR1B increased in Aire-deficient mice with significant differences noted at both 8 and 16 weeks.
Positive_regulation (increased) of SPRR1B in goblet cell
5) Confidence 0.38 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2660375 Disease Relevance 0.32 Pain Relevance 0.06
Levels of SPRR1B in the cornea were highly dependent on the presence and localization of several immune cell populations.
Positive_regulation (dependent) of SPRR1B in immune cell
6) Confidence 0.38 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.39 Pain Relevance 0.08

General Comments

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