INT265438

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Context Info
Confidence 0.72
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 15
Disease Relevance 6.76
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Sprr1b) protein binding, bridging (Sprr1b) cytoplasm (Sprr1b)
Anatomy Link Frequency
immune cell 3
T cells 3
surface epithelium 1
arms 1
effector T cells 1
Sprr1b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 435 99.88 Very High Very High Very High
Sicca syndrome 315 96.56 Very High Very High Very High
tolerance 45 83.44 Quite High
addiction 15 81.12 Quite High
cytokine 15 5.00 Very Low Very Low Very Low
Thoracotomy 15 5.00 Very Low Very Low Very Low
Pain 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 435 99.88 Very High Very High Very High
Autoimmune Disease 90 98.80 Very High Very High Very High
Metaplasia 330 97.92 Very High Very High Very High
Syndrome 330 95.92 Very High Very High Very High
Hyperplasia 15 94.84 High High
Targeted Disruption 45 93.44 High High
Disease 165 91.92 High High
Disorders Of The Lacrimal System 555 90.40 High High
Severe Combined Immunodeficiency 30 83.80 Quite High
Dry Eye 30 63.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most compelling predictors of SPRR1B expression were the presence of resident DCs in the limbus and activated DCs in the cornea (p<0.0001).
Gene_expression (expression) of SPRR1B in cornea
1) Confidence 0.72 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.45 Pain Relevance 0.11
SPRR1B expression was also largely dependent on the presence of activated DC and CD4+ T cell populations in the limbus (p?
Gene_expression (expression) of SPRR1B in T cell
2) Confidence 0.72 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.46 Pain Relevance 0.11
Superficial expression of SPRR1B was present at four weeks and progressed to a more intense full thickness staining at eight weeks in the presence of epithelial hyperplasia.
Gene_expression (expression) of SPRR1B associated with hyperplasia
3) Confidence 0.72 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.23 Pain Relevance 0
These studies allowed us to examine the hypothesis that SPRR1B expression was dependent on the extent of ocular surface damage and the level of immune cell infiltration.
Gene_expression (expression) of SPRR1B in immune cell
4) Confidence 0.72 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.42 Pain Relevance 0.14
By comparison, Aire-sufficient mice showed minimal to no expression of SPRR1B at all time points (Figure 3A,B).
Neg (no) Gene_expression (expression) of SPRR1B
5) Confidence 0.72 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.37 Pain Relevance 0.03
Infiltration of CD4+ T cells into the limbus was the next most compelling predictor of corneal SPRR1B expression (Figure 7).
Gene_expression (expression) of SPRR1B in T cells
6) Confidence 0.63 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.75 Pain Relevance 0.07
In conjunction with goblet cell drop out, corneal SPRR1B expression was increased in Aire-deficient mice.
Gene_expression (expression) of SPRR1B in goblet cell
7) Confidence 0.63 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.22 Pain Relevance 0
SPRR1B expression is related to the activation of afferent and efferent arms of the immune cycle
Gene_expression (expression) of SPRR1B in arms
8) Confidence 0.62 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.45 Pain Relevance 0.18
We show the dynamics of lissamine green staining, SPRR1B expression, goblet cell loss, and immune cell infiltration over time in the setting of Aire deficiency.
Gene_expression (expression) of SPRR1B in immune cell
9) Confidence 0.56 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 1.21 Pain Relevance 0.25
We tested the hypothesis that corneal expression of SPRR1B did not depend on each marker of ocular surface damage and inflammation (i.e., the linear term and quadratic term were both zero) using the F-test.
Gene_expression (expression) of SPRR1B associated with inflammation
10) Confidence 0.56 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.62 Pain Relevance 0.15
Together, data presented here imply a close relationship between the APC, effector T cells, and SPRR1B expression.


Gene_expression (expression) of SPRR1B in effector T cells
11) Confidence 0.56 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.49 Pain Relevance 0.13
Levels of SPRR1B in the cornea were highly dependent on the presence and localization of several immune cell populations.
Gene_expression (Levels) of SPRR1B in immune cell
12) Confidence 0.49 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.39 Pain Relevance 0.08
As shown previously, goblet cell loss and increased expression of cornified envelope precursor proteins (e.g., SPRR1B, SPRR2) denotes pathological keratinization of the mucus-secreting ocular surface epithelium [14,15].
Gene_expression (expression) of SPRR1B in surface epithelium
13) Confidence 0.49 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.21 Pain Relevance 0
Corneal infiltration of activated DCs was most prognostic of corneal SPRR1B expression while the presence of precursor DCs, activated DCs, and CD4+ T cells in the limbus were also significant predictors of SPRR1B.


Gene_expression (expression) of SPRR1B in T cells
14) Confidence 0.49 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2660375 Disease Relevance 0.31 Pain Relevance 0.03
We modeled the relationship between corneal SPRR1B expression and markers of ocular surface damage and inflammation using ordinary least squares regression (transforming both independent and dependent variables to achieve normality and homoscedasticity and to reduce the influence of specific observations).
Gene_expression (expression) of SPRR1B associated with inflammation
15) Confidence 0.49 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.19 Pain Relevance 0.05

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