INT265440

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Context Info
Confidence 0.19
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 19
Disease Relevance 10.64
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Abpe) cellular_component (Abpe) biological_process (Abpe)
Anatomy Link Frequency
meibomian glands 8
lacrimal 8
lacrimal gland 2
T cells 1
Abpe (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 36 97.72 Very High Very High Very High
Sicca syndrome 21 97.72 Very High Very High Very High
Cholecystokinin 18 96.52 Very High Very High Very High
chemokine 36 95.12 Very High Very High Very High
tolerance 3 43.20 Quite Low
antagonist 36 31.28 Quite Low
Inflammation 119 9.68 Low Low
Pain 19 5.00 Very Low Very Low Very Low
Spinal cord 18 5.00 Very Low Very Low Very Low
fibrosis 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorders Of The Lacrimal System 1567 100.00 Very High Very High Very High
Syndrome 58 97.72 Very High Very High Very High
Eye Disease 29 90.60 High High
Eyelid Disease 36 89.12 High High
Autoimmune Disease 42 74.60 Quite High
Metaplasia 40 50.00 Quite Low
Disease 11 45.16 Quite Low
Acne 18 31.52 Quite Low
Androgen Insensitivity 18 20.32 Low Low
Aging 18 17.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Comparative effects of androgens on gene expression in male and female lacrimal and meibomian glands
Gene_expression (female) of lacrimal in meibomian glands associated with disorders of the lacrimal system
1) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.46 Pain Relevance 0.14
10 fold change in the expression of over 45 lacrimal gland genes, and elicited a ?
Gene_expression (over) of lacrimal in lacrimal gland associated with disorders of the lacrimal system
2) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.76 Pain Relevance 0
10 fold change in the expression of over 45 lacrimal gland genes, and elicited a ?
Gene_expression (expression) of lacrimal in lacrimal gland associated with disorders of the lacrimal system
3) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.76 Pain Relevance 0
-estradiol and/or progesterone administration for 2 weeks significantly alters the expression of hundreds of genes in the lacrimal and meibomian glands of ovariectomized mice [41,42] (Table 12).
Gene_expression (expression) of lacrimal in meibomian glands associated with disorders of the lacrimal system
4) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.55 Pain Relevance 0
To determine the influence of testosterone on lacrimal and meibomian gland gene expression, total RNA was extracted from tissues by using TRIzol reagent (Invitrogen Corp., Carlsbad, CA).
Gene_expression (expression) of lacrimal in meibomian gland associated with disorders of the lacrimal system
5) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.35 Pain Relevance 0
Of the many androgen actions on gene expression in the lacrimal and meibomian glands, two that stand out are the stimulation of meibomian gland genes associated with lipid metabolic pathways, and the suppression of genes related to keratinization.
Gene_expression (expression) of lacrimal in meibomian gland associated with disorders of the lacrimal system
6) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.90 Pain Relevance 0
-estradiol and/or progesterone on gene expression in female lacrimal and meibomian glands
Gene_expression (expression) of lacrimal in meibomian glands associated with disorders of the lacrimal system
7) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.68 Pain Relevance 0
The 4 exceptions were genes that were significantly reduced (ratios between 2.5 to 3.6 fold) by testosterone in female mice, but were not lower following androgen exposure in male lacrimal tissues (Table 11).
Gene_expression (exposure) of lacrimal in lacrimal associated with disorders of the lacrimal system
8) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.78 Pain Relevance 0
We were especially interested in comparing the effects of the different sex steroids on gene expression in the lacrimal and meibomian glands.
Gene_expression (expression) of lacrimal in meibomian glands associated with disorders of the lacrimal system
9) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.36 Pain Relevance 0.04
We have previously discovered that testosterone treatment significantly influences the expression of over 2,000 and 1,500 genes in the lacrimal and meibomian glands, respectively, of orchiectomized mice [40].
Gene_expression (expression) of lacrimal in meibomian glands associated with disorders of the lacrimal system
10) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.41 Pain Relevance 0.14
Comparative effects of androgens on gene expression in male and female lacrimal and meibomian glands
Gene_expression (expression) of lacrimal in meibomian glands associated with disorders of the lacrimal system
11) Confidence 0.19 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.52 Pain Relevance 0.14
Infiltrating lymphocytes in Aire-deficient lacrimal glands were mainly T cells (both CD4+ and CD8+ subsets, Figure 1A).
Gene_expression (glands) of lacrimal in T cells associated with disorders of the lacrimal system
12) Confidence 0.13 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.78 Pain Relevance 0.13
-estradiol and/or progesterone administration for 2 weeks significantly alters the expression of hundreds of genes in the lacrimal and meibomian glands of ovariectomized mice [41,42] (Table 12).
Gene_expression (expression) of lacrimal in lacrimal associated with disorders of the lacrimal system
13) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.55 Pain Relevance 0
-estradiol and/or progesterone on gene expression in female lacrimal and meibomian glands
Gene_expression (expression) of lacrimal in lacrimal associated with disorders of the lacrimal system
14) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.68 Pain Relevance 0
We have previously discovered that testosterone treatment significantly influences the expression of over 2,000 and 1,500 genes in the lacrimal and meibomian glands, respectively, of orchiectomized mice [40].
Gene_expression (expression) of lacrimal in lacrimal associated with disorders of the lacrimal system
15) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.41 Pain Relevance 0.14
We were especially interested in comparing the effects of the different sex steroids on gene expression in the lacrimal and meibomian glands.
Gene_expression (expression) of lacrimal in lacrimal associated with disorders of the lacrimal system
16) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.36 Pain Relevance 0.04
To determine the influence of testosterone on lacrimal and meibomian gland gene expression, total RNA was extracted from tissues by using TRIzol reagent (Invitrogen Corp., Carlsbad, CA).
Gene_expression (expression) of lacrimal in lacrimal associated with disorders of the lacrimal system
17) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.35 Pain Relevance 0
Comparative effects of androgens on gene expression in male and female lacrimal and meibomian glands
Gene_expression (female) of lacrimal in lacrimal associated with disorders of the lacrimal system
18) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.46 Pain Relevance 0.14
Comparative effects of androgens on gene expression in male and female lacrimal and meibomian glands
Gene_expression (expression) of lacrimal in lacrimal associated with disorders of the lacrimal system
19) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.52 Pain Relevance 0.14

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