INT265441

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.65
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

histone binding (Aire) plasma membrane (Aire) nucleus (Aire)
DNA binding (Aire) cytoplasm (Aire)
Anatomy Link Frequency
brown fat cell 1
stroma 1
goblet cell 1
Aire (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 62 94.72 High High
Sicca syndrome 42 65.32 Quite High
Eae 7 60.52 Quite High
cytokine 3 31.04 Quite Low
tolerance 9 5.00 Very Low Very Low Very Low
Thoracotomy 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 119 99.44 Very High Very High Very High
INFLAMMATION 63 94.72 High High
Hyperplasia 2 85.76 High High
Targeted Disruption 46 82.08 Quite High
Metaplasia 44 76.72 Quite High
Eye Disease 22 76.20 Quite High
Disorders Of The Lacrimal System 74 69.20 Quite High
Syndrome 44 65.32 Quite High
Graft Vs Host Disease 2 54.40 Quite High
Infection 5 52.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased presence of resident and activated DCs in the Aire-deficient mouse implies the existence of autoantigen in the central cornea, either the epithelium or the stroma.
Positive_regulation (activated) of Aire in stroma
1) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.58 Pain Relevance 0.13
In conjunction with goblet cell drop out, corneal SPRR1B expression was increased in Aire-deficient mice.
Positive_regulation (increased) of Aire in goblet cell
2) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.22 Pain Relevance 0
In this sense, an increase in the gene expression levels of the recently identified transcription factor PRDM16, a positive transcriptional regulator of the brown fat cell gene program [10] was observed in iNOS-deficient mice.
Positive_regulation (increase) of regulator in brown fat cell associated with obesity
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.84 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox