INT265446

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Context Info
Confidence 0.40
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.90
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Sprr1b) protein binding, bridging (Sprr1b) cytoplasm (Sprr1b)
Anatomy Link Frequency
immune cell 2
cornea 2
Sprr1b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 87 96.96 Very High Very High Very High
Sicca syndrome 63 80.32 Quite High
tolerance 9 60.36 Quite High
addiction 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Thoracotomy 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metaplasia 66 97.92 Very High Very High Very High
INFLAMMATION 87 96.96 Very High Very High Very High
Hyperplasia 3 96.48 Very High Very High Very High
Disorders Of The Lacrimal System 111 90.40 High High
Severe Combined Immunodeficiency 6 83.80 Quite High
Syndrome 66 80.32 Quite High
Autoimmune Disease 18 71.84 Quite High
Eye Disease 33 54.32 Quite High
Disease 33 52.40 Quite High
Targeted Disruption 9 35.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show the dynamics of lissamine green staining, SPRR1B expression, goblet cell loss, and immune cell infiltration over time in the setting of Aire deficiency.
Negative_regulation (loss) of Gene_expression (expression) of SPRR1B in immune cell
1) Confidence 0.40 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 1.21 Pain Relevance 0.25
The most compelling predictors of SPRR1B expression were the presence of resident DCs in the limbus and activated DCs in the cornea (p<0.0001).
Negative_regulation (predictors) of Gene_expression (expression) of SPRR1B in cornea
2) Confidence 0.39 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.45 Pain Relevance 0.11
Superficial expression of SPRR1B was present at four weeks and progressed to a more intense full thickness staining at eight weeks in the presence of epithelial hyperplasia.
Negative_regulation (progressed) of Gene_expression (expression) of SPRR1B associated with hyperplasia
3) Confidence 0.39 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.24 Pain Relevance 0

General Comments

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