INT265448

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Context Info
Confidence 0.64
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.95
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Sprr1b) protein binding, bridging (Sprr1b) cytoplasm (Sprr1b)
Anatomy Link Frequency
immune cell 4
arms 2
goblet cell 2
T cell 2
Sprr1b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 145 99.88 Very High Very High Very High
Sicca syndrome 105 80.56 Quite High
tolerance 15 67.44 Quite High
addiction 5 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Thoracotomy 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 145 99.88 Very High Very High Very High
Metaplasia 110 91.92 High High
Disease 55 87.04 High High
Hyperplasia 5 85.12 High High
Autoimmune Disease 30 82.80 Quite High
Syndrome 110 79.92 Quite High
Disorders Of The Lacrimal System 185 61.08 Quite High
Targeted Disruption 15 38.64 Quite Low
Frailty 5 13.84 Low Low
Eye Disease 55 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SPRR1B expression was also largely dependent on the presence of activated DC and CD4+ T cell populations in the limbus (p?
Positive_regulation (dependent) of Gene_expression (expression) of SPRR1B in T cell
1) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.47 Pain Relevance 0.12
In conjunction with goblet cell drop out, corneal SPRR1B expression was increased in Aire-deficient mice.
Positive_regulation (increased) of Gene_expression (expression) of SPRR1B in goblet cell
2) Confidence 0.56 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.22 Pain Relevance 0
SPRR1B expression is related to the activation of afferent and efferent arms of the immune cycle
Positive_regulation (related) of Gene_expression (expression) of SPRR1B in arms
3) Confidence 0.46 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.45 Pain Relevance 0.18
These studies allowed us to examine the hypothesis that SPRR1B expression was dependent on the extent of ocular surface damage and the level of immune cell infiltration.
Positive_regulation (dependent) of Gene_expression (expression) of SPRR1B in immune cell
4) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.42 Pain Relevance 0.14
Levels of SPRR1B in the cornea were highly dependent on the presence and localization of several immune cell populations.
Positive_regulation (dependent) of Gene_expression (Levels) of SPRR1B in immune cell
5) Confidence 0.38 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660375 Disease Relevance 0.39 Pain Relevance 0.08

General Comments

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