INT26545

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Context Info
Confidence 0.78
First Reported 1989
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 173
Total Number 174
Disease Relevance 79.54
Pain Relevance 13.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Hras1) signal transduction (Hras1) Golgi apparatus (Hras1)
plasma membrane (Hras1) GTPase activity (Hras1)
Anatomy Link Frequency
liver 8
B-cell 7
eye 4
brain 3
joints 3
Hras1 (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 2 99.92 Very High Very High Very High
Nerve growth factor 21 99.88 Very High Very High Very High
qutenza 14 99.84 Very High Very High Very High
cytokine 475 99.72 Very High Very High Very High
Central nervous system 184 99.68 Very High Very High Very High
Inflammation 813 99.52 Very High Very High Very High
imagery 607 99.32 Very High Very High Very High
opioid receptor 10 99.28 Very High Very High Very High
bradykinin 7 99.22 Very High Very High Very High
Arthritis 1420 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 1191 100.00 Very High Very High Very High
Apoptosis 441 99.92 Very High Very High Very High
Atherosclerosis 341 99.92 Very High Very High Very High
Herpes Simplex Virus 78 99.92 Very High Very High Very High
Glioma 199 99.90 Very High Very High Very High
Targeted Disruption 2742 99.88 Very High Very High Very High
Alzheimer's Dementia 801 99.88 Very High Very High Very High
Infection 512 99.84 Very High Very High Very High
Embryonic Lethality 50 99.84 Very High Very High Very High
Cold Sores 37 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In colony screening of transgenic mice overexpressing the H-ras gene, 45% had increased LV wall thickness (> 0.9 mm), and those showing a striking increase were selected for breeding.
Gene_expression (overexpressing) of H-ras gene
1) Confidence 0.78 Published 1996 Journal Circulation Section Body Doc Link 8790053 Disease Relevance 0.16 Pain Relevance 0
Consequently, SNU-1 cells are sensitive to CAP in the overexpression of tumor suppressor gene, p53 and proto-oncogenes, c-myc and c-Ha-ras, but not those of c-erbB-2, c-jun and bcl-2 genes.
Gene_expression (overexpression) of c-Ha-ras in SNU-1 associated with qutenza and cancer
2) Confidence 0.75 Published 1997 Journal Cancer Lett. Section Abstract Doc Link 9461043 Disease Relevance 1.19 Pain Relevance 1.01
Here we demonstrate that bradykinin is also a potent mitogen for a mutant Ha-ras-transfected cell line, Rat 13.
Gene_expression (transfected) of Ha-ras associated with bradykinin
3) Confidence 0.65 Published 1989 Journal J. Cell. Sci. Section Abstract Doc Link 2561128 Disease Relevance 0.09 Pain Relevance 0.30
RFB activation of the psca promoter could be attenuated by co-transfection of dominant-negative akt and h-ras constructs, but not by dominant-negative mek1 plasmids.
Gene_expression (co-transfection) of h-ras
4) Confidence 0.65 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16949054 Disease Relevance 0.50 Pain Relevance 0.26
Estrogen and stress did not interact to elevate transgene expression in the VMH of males.
Gene_expression (expression) of transgene associated with stress
5) Confidence 0.09 Published 1997 Journal J. Neuroendocrinol. Section Abstract Doc Link 9147295 Disease Relevance 0.23 Pain Relevance 0.06
Network 7 (Figure 5A) presents NF-kappaB and HRAS in central positions and overlays with the PPAR canonic pathway (NF-kappaB, NRIP1, NR1H3, HRAS, Hsp90).
Gene_expression (presents) of HRAS
6) Confidence 0.08 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.12 Pain Relevance 0.03
We applied this U6 promoter to drive the PINK1 RNAi transgene and demonstrate the absence of any leakage of the transgene expression in all tissues of the transgenic mice and a functional recovery of the promoter upon Cre induction.
Gene_expression (expression) of transgene associated with targeted disruption
7) Confidence 0.07 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.65 Pain Relevance 0
The promoter activity was recovered after Cre-mediated excision of the stuffer sequence, and the RNAi transgene was thus expressed.
Gene_expression (expressed) of transgene
8) Confidence 0.07 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.15 Pain Relevance 0
Line #8 expressed the RNAi transgene at a higher level than line #35 and was used for further experiments.
Gene_expression (expressed) of transgene
9) Confidence 0.07 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.81 Pain Relevance 0
These findings demonstrate that stress and estrogen have sex-specific and site-specific regulatory effects on the expression of a PPE promoter transgene in hypothalamic neurons.
Gene_expression (expression) of transgene in neurons associated with stress
10) Confidence 0.07 Published 1997 Journal J. Neuroendocrinol. Section Abstract Doc Link 9147295 Disease Relevance 0.26 Pain Relevance 0
A different pattern of expression was observed in the PVN; injection of hypertonic saline induced transgene expression only in gonadally intact males and in castrated males given estrogen.
Gene_expression (expression) of transgene
11) Confidence 0.07 Published 1997 Journal J. Neuroendocrinol. Section Abstract Doc Link 9147295 Disease Relevance 0.22 Pain Relevance 0.06
In the VMH of ovariectomized females that received isotonic saline, estrogen significantly elevated transgene expression.
Gene_expression (expression) of transgene
12) Confidence 0.07 Published 1997 Journal J. Neuroendocrinol. Section Abstract Doc Link 9147295 Disease Relevance 0.28 Pain Relevance 0.07
It is demonstrated that expression of the proenkephalin transgene product was up-regulated significantly in a subset of PVN neurons 6 hours following intraperitoneal LPS (16-400 microg/kg) administration, remained elevated at 12 hours, and fell below basal levels by 24 hours.
Gene_expression (expression) of transgene in PVN
13) Confidence 0.07 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10023810 Disease Relevance 0.09 Pain Relevance 0.04
Using a line of transgenic mice overexpressing NGF among glial cells, it was first found that trigeminal ganglia from adult transgenic mice possessed significantly higher levels of NGF protein in comparison to age-matched wild-type mice; as well, detectable levels of NGF mRNA transgene expression were present in both the ganglia and brain stem.
Gene_expression (expression) of transgene in glial cells associated with targeted disruption and nerve growth factor
14) Confidence 0.06 Published 1998 Journal J. Neurobiol. Section Abstract Doc Link 9514524 Disease Relevance 0.51 Pain Relevance 0.65
The RNAi transgenic mice were generated by pronuclear injection of the transgene construct into fertilized eggs that were produced from the crossing of C57BL/6 with SJL mice.
Gene_expression (injection) of transgene in fertilized eggs associated with targeted disruption
15) Confidence 0.06 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.19 Pain Relevance 0
RNAi transgene product was detected by Northern blot in all tissues (Figure 2D, E).
Gene_expression (product) of transgene
16) Confidence 0.06 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.77 Pain Relevance 0
Nevertheless, the product of RNAi transgene was detected in different tissues of the double transgenic mice from line #35 as well as line #8.
Gene_expression (product) of transgene associated with targeted disruption
17) Confidence 0.06 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.78 Pain Relevance 0
We applied this U6 promoter to drive the PINK1 RNAi transgene and demonstrate the absence of any leakage of the transgene expression in all tissues of the transgenic mice and a functional recovery of the promoter upon Cre induction.
Gene_expression (drive) of transgene associated with targeted disruption
18) Confidence 0.06 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.62 Pain Relevance 0.05
The three groups are a.) mice not harbouring any transgene ("wt"), b.) mice harbouring only the BEG2 transgene (which do not express G-CSF), and c.) mice harbouring both the BEG2 transgene and the CaMKII-tTA driver, that do express G-CSF.
Gene_expression (harbouring) of transgene
19) Confidence 0.06 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.50 Pain Relevance 0.17
The three groups are a.) mice not harbouring any transgene ("wt"), b.) mice harbouring only the BEG2 transgene (which do not express G-CSF), and c.) mice harbouring both the BEG2 transgene and the CaMKII-tTA driver, that do express G-CSF.
Neg (not) Gene_expression (express) of transgene
20) Confidence 0.06 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844381 Disease Relevance 0.45 Pain Relevance 0.19

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