INT26546

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Context Info
Confidence 0.70
First Reported 1989
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 35
Total Number 37
Disease Relevance 16.59
Pain Relevance 4.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Hras1) signal transduction (Hras1) Golgi apparatus (Hras1)
plasma membrane (Hras1) GTPase activity (Hras1)
Anatomy Link Frequency
PVN 6
microglial cells 4
eye 4
lungs 4
spleen 3
Hras1 (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 1 99.92 Very High Very High Very High
cytokine 114 99.90 Very High Very High Very High
Nerve growth factor 13 99.88 Very High Very High Very High
qutenza 14 99.84 Very High Very High Very High
Inflammation 178 99.70 Very High Very High Very High
Central nervous system 56 99.68 Very High Very High Very High
bradykinin 7 99.22 Very High Very High Very High
Pain 10 98.22 Very High Very High Very High
Enkephalin 8 98.22 Very High Very High Very High
nociceptor 2 98.22 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 98 100.00 Very High Very High Very High
Herpes Simplex Virus 25 99.92 Very High Very High Very High
INFLAMMATION 186 99.70 Very High Very High Very High
Central Nervous System Disease 48 99.68 Very High Very High Very High
Stress 36 99.58 Very High Very High Very High
Disease 141 99.40 Very High Very High Very High
Targeted Disruption 309 99.32 Very High Very High Very High
Hyperlipoproteinemia Type Ii 132 98.92 Very High Very High Very High
Cold Sores 10 98.76 Very High Very High Very High
Injury 52 98.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In colony screening of transgenic mice overexpressing the H-ras gene, 45% had increased LV wall thickness (> 0.9 mm), and those showing a striking increase were selected for breeding.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of H-ras gene
1) Confidence 0.70 Published 1996 Journal Circulation Section Body Doc Link 8790053 Disease Relevance 0.16 Pain Relevance 0
Here we demonstrate that bradykinin is also a potent mitogen for a mutant Ha-ras-transfected cell line, Rat 13.
Positive_regulation (transfected) of Gene_expression (transfected) of Ha-ras associated with bradykinin
2) Confidence 0.49 Published 1989 Journal J. Cell. Sci. Section Abstract Doc Link 2561128 Disease Relevance 0.09 Pain Relevance 0.30
Consequently, SNU-1 cells are sensitive to CAP in the overexpression of tumor suppressor gene, p53 and proto-oncogenes, c-myc and c-Ha-ras, but not those of c-erbB-2, c-jun and bcl-2 genes.
Positive_regulation (overexpression) of Gene_expression (overexpression) of c-Ha-ras in SNU-1 associated with qutenza and cancer
3) Confidence 0.49 Published 1997 Journal Cancer Lett. Section Abstract Doc Link 9461043 Disease Relevance 1.19 Pain Relevance 1.01
RFB activation of the psca promoter could be attenuated by co-transfection of dominant-negative akt and h-ras constructs, but not by dominant-negative mek1 plasmids.
Positive_regulation (co-transfection) of Gene_expression (co-transfection) of h-ras
4) Confidence 0.49 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16949054 Disease Relevance 0.50 Pain Relevance 0.26
In the VMH of ovariectomized females that received isotonic saline, estrogen significantly elevated transgene expression.
Positive_regulation (elevated) of Gene_expression (expression) of transgene
5) Confidence 0.05 Published 1997 Journal J. Neuroendocrinol. Section Abstract Doc Link 9147295 Disease Relevance 0.28 Pain Relevance 0.07
Estrogen and stress did not interact to elevate transgene expression in the VMH of males.
Positive_regulation (elevate) of Gene_expression (expression) of transgene associated with stress
6) Confidence 0.05 Published 1997 Journal J. Neuroendocrinol. Section Abstract Doc Link 9147295 Disease Relevance 0.23 Pain Relevance 0.06
A different pattern of expression was observed in the PVN; injection of hypertonic saline induced transgene expression only in gonadally intact males and in castrated males given estrogen.
Positive_regulation (induced) of Gene_expression (expression) of transgene
7) Confidence 0.05 Published 1997 Journal J. Neuroendocrinol. Section Abstract Doc Link 9147295 Disease Relevance 0.22 Pain Relevance 0.06
Line #8 expressed the RNAi transgene at a higher level than line #35 and was used for further experiments.
Positive_regulation (level) of Gene_expression (expressed) of transgene
8) Confidence 0.04 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.81 Pain Relevance 0
It is demonstrated that expression of the proenkephalin transgene product was up-regulated significantly in a subset of PVN neurons 6 hours following intraperitoneal LPS (16-400 microg/kg) administration, remained elevated at 12 hours, and fell below basal levels by 24 hours.
Positive_regulation (up-regulated) of Gene_expression (expression) of transgene in PVN
9) Confidence 0.04 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10023810 Disease Relevance 0.09 Pain Relevance 0.04
It is demonstrated that expression of the proenkephalin transgene product was up-regulated significantly in a subset of PVN neurons 6 hours following intraperitoneal LPS (16-400 microg/kg) administration, remained elevated at 12 hours, and fell below basal levels by 24 hours.
Positive_regulation (elevated) of Gene_expression (expression) of transgene in PVN
10) Confidence 0.04 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10023810 Disease Relevance 0.09 Pain Relevance 0.04
Real-time PCR analysis failed to detect an upregulation of the OSA1 and STAT1 genes in the brain and spleen tissues of PINK1 RNAi transgenic mice (Figure 4), indicating that expression of the PINK1 shRNA transgene did not induce significant interferon response.


Neg (not) Positive_regulation (induce) of Gene_expression (expression) of transgene in spleen associated with targeted disruption
11) Confidence 0.04 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.32 Pain Relevance 0.09
Up-regulation of transgene expression does not appear to result from local action of IL-1beta at the level of the PVN but, rather, through as yet unidentified intermediates.
Positive_regulation (Up-regulation) of Gene_expression (expression) of transgene in PVN
12) Confidence 0.04 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10023810 Disease Relevance 0.06 Pain Relevance 0.08
Transgene expression was not up-regulated in hypothalamic slice cultures treated directly with IL-1beta (5-10 ng/ml media).
Neg (not) Positive_regulation (up-regulated) of Gene_expression (expression) of Transgene
13) Confidence 0.04 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10023810 Disease Relevance 0.06 Pain Relevance 0.03
Using a line of transgenic mice overexpressing NGF among glial cells, it was first found that trigeminal ganglia from adult transgenic mice possessed significantly higher levels of NGF protein in comparison to age-matched wild-type mice; as well, detectable levels of NGF mRNA transgene expression were present in both the ganglia and brain stem.
Positive_regulation (present) of Gene_expression (expression) of transgene in glial cells associated with targeted disruption and nerve growth factor
14) Confidence 0.04 Published 1998 Journal J. Neurobiol. Section Abstract Doc Link 9514524 Disease Relevance 0.51 Pain Relevance 0.65
A recent study found that administration of Ad 10-20 weeks after AAV gene transfer augmented AAV transgene expression two-fold by increasing the level of pro-viral mRNA [149] and this strategy may prove useful in clinical practice when transgenic protein expression levels fall.
Positive_regulation (augmented) of Gene_expression (expression) of transgene associated with targeted disruption
15) Confidence 0.03 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.21 Pain Relevance 0
In addition, a sensitive non-invasive method using a scintillation camera is available to determine the location, magnitude, and duration of LDLR transgene expression which could provide functional transgene expression in gene therapy trials of FH [74].
Positive_regulation (provide) of Gene_expression (expression) of transgene associated with hyperlipoproteinemia type ii
16) Confidence 0.03 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.94 Pain Relevance 0
Similarly, a low level of rAdv-hTERTC27 greatly enhanced the expression of hTERTC27 transgene carried by rAAV, and rAAV-/rAdv-hTERTC27 viral cocktail potently inhibited xenografted glioblastoma growth [30].
Positive_regulation (enhanced) of Gene_expression (expression) of transgene associated with glioblastoma
17) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938346 Disease Relevance 1.21 Pain Relevance 0
After initial screening of founders, we identified four lines of tet-APPswe/ind mice that produced very high levels of transgene product in offspring coexpressing tTA (Figures 1 and Figure S1).
Positive_regulation (levels) of Gene_expression (produced) of transgene
18) Confidence 0.02 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.47 Pain Relevance 0
Real-time PCR analysis failed to detect an upregulation of the OSA1 and STAT1 genes in the brain and spleen tissues of PINK1 RNAi transgenic mice (Figure 4), indicating that expression of the PINK1 shRNA transgene did not induce significant interferon response.


Neg (not) Positive_regulation (induce) of in brain Gene_expression (expression) of transgene in spleen associated with targeted disruption
19) Confidence 0.01 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.32 Pain Relevance 0.09
As shown in Fig. 1, the rAAV2 transgene is rapidly transferred and expressed in both the lungs (panel A) and intestines (panel B).
Positive_regulation (transferred) of Gene_expression (transferred) of rAAV2 transgene in lungs
20) Confidence 0.01 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC239997 Disease Relevance 0.22 Pain Relevance 0

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