INT265463

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.60
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (CSPG4) extracellular space (IL6) aging (IL6)
extracellular region (IL6) plasma membrane (CSPG4) intracellular (CSPG4)
CSPG4 (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 18 97.64 Very High Very High Very High
Inflammation 20 96.68 Very High Very High Very High
antagonist 2 62.88 Quite High
Pain 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 24 99.46 Very High Very High Very High
INFLAMMATION 20 96.68 Very High Very High Very High
Apoptosis 48 78.00 Quite High
Stress 24 73.80 Quite High
Lymphatic System Cancer 2 60.60 Quite High
Necrosis 4 34.44 Quite Low
Cancer 4 34.08 Quite Low
Disorders Of The Lacrimal System 6 5.00 Very Low Very Low Very Low
Dry Eye 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HMW-HA decreased HCE cell death, and it could explain how HMW-HA decreased IL-6 and IL-8 observed production.
HMW-HA Negative_regulation (decreased) of Gene_expression (production) of IL-6 associated with death
1) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0.77 Pain Relevance 0.27
We suggested that HMW-HA indirectly prevents IL-6 and IL-8 production in HCE cells by decreasing cell death as well as prevents cytokine release via CD44 with a direct inhibition of the inflammation process.
HMW-HA Negative_regulation (prevents) of Gene_expression (production) of IL-6 associated with inflammation, death and cytokine
2) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0.83 Pain Relevance 0.29

General Comments

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