INT265492

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 2009
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.61
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP9) peptidase activity (CASP9) nucleus (CASP9)
intracellular (CASP9)
Anatomy Link Frequency
endothelial cells 2
CASP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 23 50.00 Quite Low
antagonist 5 19.84 Low Low
Bile 5 17.00 Low Low
agonist 25 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 300 99.12 Very High Very High Very High
Apoptosis 85 97.92 Very High Very High Very High
Death 37 93.68 High High
Pancreatic Cancer 21 91.92 High High
Cancer 19 87.84 High High
Necrosis 5 87.36 High High
Increased Venous Pressure Under Development 20 86.72 High High
Aggression 2 85.60 High High
Adhesions 5 84.72 Quite High
Thrombosis 4 73.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HDL has been implicated in curtailing the apoptosis and promoting the proliferation and migration of endothelial cells especially when damaged through the inhibition of the activation of caspase- 3 and caspase-9.
Negative_regulation (inhibition) of Positive_regulation (activation) of caspase-9 in endothelial cells associated with apoptosis and disorder of lipid metabolism
1) Confidence 0.57 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.27 Pain Relevance 0
Following caspase-9 activation, Pro-caspase-3 expression was downregulated significantly.
Negative_regulation (downregulated) of Positive_regulation (activation) of caspase-9
2) Confidence 0.24 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.78 Pain Relevance 0
HCE cells treated with HMW-HA exhibited a significant decrease in UVB-induced capase-8 activation but few or no decrease in caspase-9 activation.
Neg (no) Negative_regulation (decrease) of Positive_regulation (activation) of caspase-9
3) Confidence 0.21 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 1.26 Pain Relevance 0
-actin, H2O2 treatment alone showed a slight decrease in the level of Bcl-2 to 0.95 fold of control but a large increase in the level of tBid, Apaf-1 and cytosolic CytC, the coactivators of apoptosome for the activation of caspase-9, to 4.81, 1.06, and 1.75 fold of control, respectively.
Negative_regulation (decrease) of Positive_regulation (activation) of caspase-9
4) Confidence 0.06 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952314 Disease Relevance 0.30 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox