INT26555

Context Info Confidence 0.59 First Reported 1987 Last Reported 2008 Negated 1 Speculated 4 Reported most in Abstract Documents 6 Total Number 10 Disease Relevance 2.47 Pain Relevance 5.76

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

Anatomy Link Frequency cleavage 2 LPBN 2 Oprd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Opioid 139 100.00 opioid receptor 127 100.00 Morphine 36 100.00 narcan 21 100.00 Kinase C 13 100.00 alcohol 9 100.00 agonist 31 99.84 Inflammation 65 99.68 Calcium channel 4 99.68 excitatory amino acid 2 98.96

Disease Link Frequency Relevance Heat Lordosis 9 99.96 INFLAMMATION 70 99.68 Diuresis 1 98.08 Natriuresis 2 96.28 Headache 7 95.00 Pain 38 81.40 Neuroblastoma 1 80.08 Miosis 1 72.72 Targeted Disruption 3 55.52 Osteoarthritis 1 54.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Effects of continuous opioid receptor blockade on alcohol intake and up-regulation of opioid receptor subtype signalling in a genetic model of high alcohol drinking.

Regulation (Effects) of Positive_regulation (up-regulation) of opioid receptor associated with narcan, opioid receptor and alcohol

1) Confidence 0.59 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 10551276 Disease Relevance 0 Pain Relevance 0.86

The aim of the present study was to investigate whether such an abnormal response to morphine challenge is entirely dependent on opioid receptor activation.

Spec (whether) Regulation (dependent) of Spec (whether) Positive_regulation (activation) of opioid receptor associated with opioid receptor and morphine

2) Confidence 0.43 Published 1998 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 9675625 Disease Relevance 0.52 Pain Relevance 1.31

Therefore, in the present study we investigated the effects of opioid receptor activation in the LPBN on 0.3 M NaCl and water intake in rats.

Spec (investigated) Regulation (effects) of Spec (investigated) Positive_regulation (activation) of opioid receptor in LPBN associated with opioid receptor

3) Confidence 0.27 Published 2008 Journal Neuroscience Section Abstract Doc Link 18602454 Disease Relevance 0 Pain Relevance 0.55

These results indicate that the specific activation of opioid receptor subtypes differentially affects lordosis behavior.

Regulation (affects) of Positive_regulation (activation) of opioid receptor associated with opioid receptor and lordosis

4) Confidence 0.24 Published 1987 Journal Peptides Section Abstract Doc Link 3035514 Disease Relevance 0.70 Pain Relevance 0.37

The mechanisms that affect opioid receptor upregulation during inflammation are not yet well understood, however, a number of recent studies provide insight into these mechanisms.

Regulation (affect) of Positive_regulation (upregulation) of opioid receptor associated with inflammation and opioid receptor

5) Confidence 0.14 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.97 Pain Relevance 0.87

CONCLUSIONS: Intrathecal opiate-induced granulomas are not strictly dependent on opioid receptor activation.

Neg (not) Regulation (dependent) of Positive_regulation (activation) of opioid receptor

6) Confidence 0.13 Published 2006 Journal Anesthesiology Section Body Doc Link 16931994 Disease Relevance 0 Pain Relevance 0

In the present study, we determined if calcium channel blockade would affect increases in opioid receptor density and functional supersensitivity produced by chronic opioid antagonist treatment in the mouse.

Regulation (affect) of Positive_regulation (increases) of opioid receptor associated with antagonist, calcium channel, opioid receptor and opioid

7) Confidence 0.08 Published 2000 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 10880689 Disease Relevance 0 Pain Relevance 0.77

It is suggested that disulfide bonds are essential for ligand binding and that cleavage of one or more of these bonds may play a role in opioid receptor activation by agonists.

Regulation (role) of Positive_regulation (activation) of opioid receptor in cleavage associated with agonist and opioid receptor

8) Confidence 0.02 Published 1989 Journal J. Mol. Recognit. Section Abstract Doc Link 2561526 Disease Relevance 0 Pain Relevance 0.28

The purpose of the current study is to investigate the effect of opioid-independent, heterologous activation of protein kinase C (PKC) on the responsiveness of opioid receptor and the underlying molecular mechanisms.

Spec (investigate) Regulation (effect) of Positive_regulation (responsiveness) of opioid receptor associated with kinase c, opioid receptor and opioid

9) Confidence 0.01 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11085981 Disease Relevance 0 Pain Relevance 0.59

The objective of the present study was to examine the effect of opioid receptor stimulation by morphine after surgery on endogenous ANF production and diuresis.

Spec (examine) Regulation (effect) of Spec (examine) Positive_regulation (stimulation) of opioid receptor associated with diuresis, opioid receptor and morphine

10) Confidence 0.01 Published 2000 Journal Clin Exp Obstet Gynecol Section Abstract Doc Link 10968348 Disease Relevance 0.27 Pain Relevance 0.15

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