INT265552

Context Info Confidence 0.18 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 6 Disease Relevance 4.54 Pain Relevance 0

extracellular region (Gla) Golgi apparatus (Gla) biological_process (Gla) lysosome (Gla) cytoplasm (Gla)

Gla (Rattus norvegicus)

Pain Link Frequency Relevance Heat metalloproteinase 24 41.92 analgesia 6 5.00 ketamine 6 5.00

Disease Link Frequency Relevance Heat Apoptosis 30 99.40 Glioma 144 99.16 Cancer 258 97.28 Malignant Neoplastic Disease 6 65.68 Metastasis 6 5.00 Neuroblastoma 6 5.00 Overdose 6 5.00 Body Weight 6 5.00 Breast Cancer 6 5.00 Colon Cancer 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Both GLA and its metabolic products can alter the gene expression of several proteins and GLA is known to inhibit glioma cell migration [14-16].

Gene_expression (expression) of GLA associated with glioma

1) Confidence 0.18 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 1.28 Pain Relevance 0

The present study infused 5 mM GLA at 0.5 ?

Gene_expression (infused) of GLA

2) Confidence 0.17 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.80 Pain Relevance 0

GAPDH expression remained unchanged after GLA exposure.

Gene_expression (exposure) of GLA

3) Confidence 0.17 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0 Pain Relevance 0

During in vivo studies infusion of 2 mM GLA at 1 ?

Gene_expression (infusion) of GLA

4) Confidence 0.17 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.85 Pain Relevance 0

Zymography confirmed a significant decrease (32 ± 8.5%) in proteolytic activity of MMP2 in the presence of GLA (Figure 2B).

Gene_expression (presence) of GLA

5) Confidence 0.17 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.44 Pain Relevance 0

Both GLA and its metabolic products can alter the gene expression of several proteins and GLA is known to inhibit glioma cell migration [14-16].

Gene_expression (products) of GLA associated with glioma

6) Confidence 0.17 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 1.17 Pain Relevance 0

General Comments

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