INT265559

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Context Info
Confidence 0.13
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.01
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ocln) plasma membrane (Ocln) cytoplasm (Ocln)
Anatomy Link Frequency
endothelial cells 2
brain 2
Ocln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 4 89.56 High High
Central nervous system 4 37.88 Quite Low
ischemia 5 32.40 Quite Low
ketamine 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Intracerebroventricular 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 6 96.68 Very High Very High Very High
Glioma 24 91.80 High High
Cancer 43 84.12 Quite High
Malignant Neoplastic Disease 1 77.32 Quite High
Brain Hemorrhage 2 33.60 Quite Low
Hypoxia 3 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 3 5.00 Very Low Very Low Very Low
Brain Injury 3 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we show that the protein levels of occludin and ZO-1 are not altered, but instead their interaction is considerably reduced in the sonicated brain areas, suggesting that the decrease in immunogold signals may be the consequence of the redistribution of tight junction proteins.
Regulation (altered) of Gene_expression (levels) of occludin in brain
1) Confidence 0.13 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
Several studies have reported GLA-induced changes in endothelial cells including altered occludin and VE-cadherin expression and altered barrier properties [21,22].
Regulation (altered) of Gene_expression (expression) of occludin in endothelial cells
2) Confidence 0.08 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 1.01 Pain Relevance 0.04

General Comments

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