INT265575

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Context Info
Confidence 0.30
First Reported 2009
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 7.66
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Msc) DNA binding (Msc)
Anatomy Link Frequency
endothelial cells 1
head 1
A549 1
Msc (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 18 86.12 High High
imagery 45 75.12 Quite High
cytokine 36 63.40 Quite High
anesthesia 9 5.00 Very Low Very Low Very Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 1241 99.80 Very High Very High Very High
Lymphatic System Cancer 186 99.80 Very High Very High Very High
Small Cell Lung Carcinoma 6 98.96 Very High Very High Very High
Necrosis 49 96.56 Very High Very High Very High
Hypoxia 81 91.36 High High
Severe Combined Immunodeficiency 34 84.36 Quite High
Skin Cancer 27 82.48 Quite High
Apoptosis 38 82.08 Quite High
Breast Cancer 22 81.68 Quite High
Glioma 6 80.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-SMA+ cell incorporation throughout the stromal compartment at variance of the scant SMA+ perivascular pattern predominantly observed in the absence of MSC.
MSC Neg (absence) Binding (absence) of
1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 1.07 Pain Relevance 0
Although some controversial data are present on the role of MSC in cancer development and/or therapy [35], [36], several novel conclusions can be summarized from our study: i) the in vitro interaction of BM-derived MSC and lymphoma cells poorly predicts the in vivo effect of MSC on the survival of xenograft bearing animals; ii) MSC significantly modulate the stromal network of lymphomas in vivo, by increasing the number of ?
MSC Binding (interaction) of associated with lymphatic system cancer and cancer
2) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 0.83 Pain Relevance 0.03
Based on these observations, in the last group of experiments we have investigated the effect of a direct interaction between MSC and endothelial cells.
MSC Binding (interaction) of in endothelial cells
3) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 0.14 Pain Relevance 0.06
Control mice were sacrificed for IHC comparison to the Skov-3/MSC 50?
MSC Binding (comparison) of
4) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.30 Pain Relevance 0.03
The first indication that MSC had a natural affinity for tumors was reported by our group in 2001 [30].
MSC Binding (affinity) of associated with cancer
5) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.98 Pain Relevance 0
MSC-secreted EGF, in vitro, is not sufficient to enhance Skov-3 proliferation as seen with MSC-secreted IL-6.
MSC-secreted Binding (seen) of
6) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.48 Pain Relevance 0
We then monitored MSC recruitment by GFP immunohistochemical staining and found a pattern similar to that seen with BMDC recruitment (Figure 4).
MSC Binding (recruitment) of
7) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944821 Disease Relevance 0.06 Pain Relevance 0.11
Changes in vascular volume and permeability were estimated in tumor-bearing mice following treatment with MSC (0.2?
MSC Binding (following) of associated with cancer
8) Confidence 0.05 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2860580 Disease Relevance 1.02 Pain Relevance 0
In combination with MSC there was no significant improvement in CR except in WDSCC where the CR increased to 14%.
MSC Neg (except) Binding (combination) of
9) Confidence 0.05 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2860580 Disease Relevance 0.70 Pain Relevance 0
In contrast, the moderately differentiated non-small cell lung carcinoma A549 had 0% cures either with the drug alone or in combination with MSC.
MSC Binding (combination) of in A549 associated with small cell lung carcinoma
10) Confidence 0.05 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2860580 Disease Relevance 1.08 Pain Relevance 0
These findings indicate that intravenously injected MSC could migrate into the femoral head and stayed in the femoral head for a relatively long time (Figure 4 A-F).


MSC Binding (migrate) of in head
11) Confidence 0.03 Published 2011 Journal International Journal of Medical Sciences Section Body Doc Link PMC3020395 Disease Relevance 0 Pain Relevance 0.11

General Comments

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