INT265580

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Context Info
Confidence 0.28
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.78
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Fap) extracellular space (Fap) plasma membrane (Fap)
Anatomy Link Frequency
fibroblasts 4
Fap (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 11 79.68 Quite High
imagery 21 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Amyloidotic Polyneuropathy 21 100.00 Very High Very High Very High
Disease 7 99.60 Very High Very High Very High
Alzheimer's Dementia 32 98.48 Very High Very High Very High
Cancer 398 98.24 Very High Very High Very High
Amyloid Plaque 12 85.84 High High
Ovarian Cancer 10 75.72 Quite High
Aggression 12 69.52 Quite High
Pancreatic Cancer 6 65.96 Quite High
Stress 11 50.64 Quite High
Death 6 50.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biglycan is elevated both in FAP patients and in FAP mice models early in disease development, before amyloid is evident.
Positive_regulation (elevated) of Gene_expression (models) of FAP associated with familial amyloidotic polyneuropathy, alzheimer's dementia and disease
1) Confidence 0.28 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.78 Pain Relevance 0.04
The first characteristic requires expression of two fibroblastic markers: FAP, which is expressed on MSC and fibroblasts [40] and FSP, a marker overexpressed in TAF as compared to normal fibroblasts [41].
Positive_regulation (requires) of Gene_expression (expressed) of FAP in fibroblasts
2) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.01 Pain Relevance 0.03
The first characteristic requires expression of two fibroblastic markers: FAP, which is expressed on MSC and fibroblasts [40] and FSP, a marker overexpressed in TAF as compared to normal fibroblasts [41].
Positive_regulation (requires) of Gene_expression (expression) of FAP in fibroblasts
3) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.00 Pain Relevance 0.03

General Comments

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