INT265581

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Context Info
Confidence 0.19
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.01
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Msc) DNA binding (Msc)
Anatomy Link Frequency
TAF 2
white matter 2
Msc (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 12 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 200 100.00 Very High Very High Very High
Aggression 6 98.08 Very High Very High Very High
Apoptosis 5 97.12 Very High Very High Very High
Middle Cerebral Artery Infarction 17 94.56 High High
Stroke 27 89.76 High High
Neurodegenerative Disease 3 86.72 High High
Glioma 2 76.24 Quite High
Breast Cancer 7 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Ovarian Cancer 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that, although we cannot exclude a contribution of MSC induced neuroprotection to the MSC mediated increase in axonal fiber density and synaptophysin expression, the reduction in apoptosis likely plays a minor role in the observed white matter remodeling.


Positive_regulation (mediated) of Positive_regulation (increase) of MSC in white matter associated with apoptosis
1) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 1.12 Pain Relevance 0
We show the “activation” of MSC by tumor conditioned media by the increase of TAF-like surface markers (Figure 1A).
Positive_regulation (increase) of Positive_regulation (activation) of MSC in TAF associated with cancer
2) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.89 Pain Relevance 0

General Comments

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