INT265583

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Context Info
Confidence 0.61
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 6.37
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Msc) DNA binding (Msc)
Anatomy Link Frequency
endothelial cells 1
capillary 1
astrocytes 1
fibroblast 1
Msc (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 9 83.36 Quite High
cytokine 31 79.40 Quite High
ischemia 5 70.08 Quite High
Spinal cord 1 69.28 Quite High
cva 1 69.04 Quite High
imagery 52 26.88 Quite Low
metalloproteinase 15 5.00 Very Low Very Low Very Low
chemokine 15 5.00 Very Low Very Low Very Low
isoflurane 14 5.00 Very Low Very Low Very Low
anesthesia 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 124 99.78 Very High Very High Very High
Cancer 1050 99.66 Very High Very High Very High
Apoptosis 23 98.08 Very High Very High Very High
Necrosis 11 94.64 High High
Aggression 30 91.40 High High
Hypoxia 1 90.92 High High
Stroke 27 83.88 Quite High
Cv General 4 Under Development 1 70.80 Quite High
Hemorrhage 1 69.04 Quite High
Malignant Neoplastic Disease 4 55.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The injection of MSC delayed the development of the peritoneal tumoral masses of the NHL xenografts, and at necroscopic analysis, tumor specimens developed in the absence or presence of MSC showed significant histological differences, which can be recapitulated as follow: while BJAB- and/or SKW6.4-derived peritoneal masses showed the typical faint capillary network also described in human NHL [27], the presence of MSC promoted a diffuse increase in ?
Localization (presence) of MSC in capillary associated with lymphatic system cancer and cancer
1) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 1.28 Pain Relevance 0
Since MSC release a cocktail of potent pro-angiogenic factors [28]–[30], we have next examined the ability of MSC to drive the migration of endothelial cells.
Localization (release) of MSC in endothelial cells
2) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 0.29 Pain Relevance 0.10
The concomitant MSC induced reduction of PAI-1 and increase of tPA in astrocytes of the IBZ thereby amplify tPA activity which contributes to neurite outgrowth.
Localization (reduction) of MSC in astrocytes
3) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.72 Pain Relevance 0.15
Growth factors that support tumor cell growth are secreted by both MSC and the tumor cells when reciprocally stimulated by one another.
Localization (secreted) of MSC associated with cancer
4) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.76 Pain Relevance 0
MSC secreted growth factors support Skov-3 cell proliferation
Localization (secreted) of MSC
5) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.80 Pain Relevance 0
An initial ELISA array of several growth factors secreted by MSC shows a significantly increased secretion (P<0.001) of TGF-?
Localization (secreted) of MSC
6) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.75 Pain Relevance 0
MSC can secrete growth factors to support tumor cell growth.
Localization (secrete) of MSC associated with cancer
7) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.51 Pain Relevance 0
To support our hypothesis that MSC contribute to the TAF population within the tumor microenvironment, we stained the admixed and Skov-3 only tumors sections for four different TAF characteristics: fibroblast surface markers, markers of vascularization, markers of invasiveness and aggressiveness and expression of tumor-promoting growth factors (Figure 1B).
Localization (population) of MSC in fibroblast associated with cancer and aggression
8) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.26 Pain Relevance 0

General Comments

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