INT265606

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.42
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TAF8) nucleolus (TAF8) nucleus (TAF8)
DNA binding (TAF8) cytoplasm (TAF8)
Anatomy Link Frequency
stem cells 2
TAF 1
TAF8 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 67 96.24 Very High Very High Very High
chemokine 12 86.72 High High
cytokine 12 86.24 High High
addiction 4 25.00 Low Low
metalloproteinase 12 11.32 Low Low
spinal stenosis 14 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
isoflurane 8 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 797 99.48 Very High Very High Very High
Adenocarcinoma 8 97.52 Very High Very High Very High
Solid Tumor 4 96.92 Very High Very High Very High
Aggression 24 95.96 Very High Very High Very High
Ovarian Cancer 20 85.44 High High
Injury 8 82.72 Quite High
Glioma 8 76.80 Quite High
Obesity 14 75.16 Quite High
Osteoarthritis 1 15.76 Low Low
Breast Cancer 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using the calculated TAF and TAT as the standard, the correlation between the walking capacity and radiology was assessed.
Positive_regulation (calculated) of TAF
1) Confidence 0.35 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2810595 Disease Relevance 0 Pain Relevance 0.20
This possibility would also account for the increase in TbN in the alendronate group without a change in BV/TV as alendronate increases secondary mineralization (even though no increase in tissue density was detected at 1 year) by suppressing remodeling [11, 13].
Positive_regulation (increase) of TbN
2) Confidence 0.22 Published 2010 Journal Rheumatol Int Section Body Doc Link PMC2908746 Disease Relevance 0 Pain Relevance 0
TbN increased in the strontium ranelate and alendronate groups, (4.2 ± 8.2%, P = 0.011, and 4.3 ± 10.7%, P = 0.030, respectively) with a corresponding decrease in trabeculae spacing (TbSp; ?
Positive_regulation (increased) of TbN
3) Confidence 0.22 Published 2010 Journal Rheumatol Int Section Body Doc Link PMC2908746 Disease Relevance 0 Pain Relevance 0
The ability of MSC to travel to solid tumors after intravenous administration and their ability to develop myofibroblast-like characteristics under defined culture conditions [20] both suggest that TAF could be derived from MSC.
Positive_regulation (derived) of TAF associated with solid tumor
4) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.29 Pain Relevance 0
We show the “activation” of MSC by tumor conditioned media by the increase of TAF-like surface markers (Figure 1A).
Positive_regulation (increase) of TAF in TAF associated with cancer
5) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.88 Pain Relevance 0
We provide evidence that TAF are derived from mesenchymal stem cells (MSC) that acquire a TAF phenotype following exposure to or systemic recruitment into adenocarcinoma xenograft models including breast, pancreatic, and ovarian.
Positive_regulation (derived) of TAF in stem cells associated with adenocarcinoma
6) Confidence 0.08 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2661372 Disease Relevance 0.63 Pain Relevance 0.09
We provide evidence that TAF are derived from mesenchymal stem cells (MSC) that acquire a TAF phenotype following exposure to or systemic recruitment into adenocarcinoma xenograft models including breast, pancreatic, and ovarian.
Positive_regulation (acquire) of TAF in stem cells associated with adenocarcinoma
7) Confidence 0.08 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2661372 Disease Relevance 0.63 Pain Relevance 0.08

General Comments

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