INT265659

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.78
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (COMT) mitochondrion (COMT) small molecule metabolic process (COMT)
plasma membrane (COMT) cytoplasm (COMT)
COMT (Homo sapiens)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 222 100.00 Very High Very High Very High
Pain 44 99.96 Very High Very High Very High
Face pain 4 98.64 Very High Very High Very High
Catecholamine 6 98.32 Very High Very High Very High
Central nervous system 10 92.60 High High
IPN 12 78.88 Quite High
Dopamine 2 40.80 Quite Low
noradrenaline 2 39.76 Quite Low
Lasting pain 2 7.52 Low Low
Inflammation 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 44 99.96 Very High Very High Very High
Facial Pain 4 98.64 Very High Very High Very High
Manic Depressive Disorder 2 92.56 High High
Schizophrenia 2 91.68 High High
Cancer 6 90.40 High High
Inflammatory Pain 12 78.88 Quite High
Anaplastic Astrocytoma 16 73.84 Quite High
INFLAMMATION 20 5.00 Very Low Very Low Very Low
Neuropathic Pain 8 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Myofacial pain patients exhibit lower COMT activity relative to controls [7], and COMT inhibition increases pain sensitivity in rodents by promoting catecholamine stimulation of ?
Positive_regulation (increases) of Negative_regulation (inhibition) of COMT associated with pain, catechol-o-methyltransferase, catecholamine and face pain
1) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.37 Pain Relevance 1.08
-dependent COMT downregulation was indeed mediated by the NF-?
Positive_regulation (mediated) of Negative_regulation (downregulation) of COMT associated with catechol-o-methyltransferase
2) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.41 Pain Relevance 0.48

General Comments

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