INT265661

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Context Info
Confidence 0.09
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.69
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
mononuclear cells 2
HIST2H4A (Homo sapiens)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 111 94.88 High High
Pain 22 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
IPN 6 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
abdominal pain 4 5.00 Very Low Very Low Very Low
Catecholamine 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 97 99.56 Very High Very High Very High
Hypocalcemia 2 99.48 Very High Very High Very High
Hypoalbuminemia 4 98.72 Very High Very High Very High
Vomiting 58 98.04 Very High Very High Very High
Anorexia 8 97.32 Very High Very High Very High
Fatigue 36 96.92 Very High Very High Very High
Neurologic Gait Disorders 2 94.80 High High
Toxicity 22 93.64 High High
Skin Cancer 2 92.72 High High
Infection 4 92.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
treatment in either H4 or H4 I?
Positive_regulation (either) of Gene_expression (either) of H4
1) Confidence 0.09 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.07 Pain Relevance 0.28
Histone H3/H4 acetylation, p21 expression, and caspase-3 activation can be induced by MS-275 in bone marrow mononuclear cells.
Positive_regulation (induced) of Gene_expression (acetylation) of H4 in mononuclear cells
2) Confidence 0.06 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2827364 Disease Relevance 1.61 Pain Relevance 0
Levels of histone H3 and H4 acetylation in PBMCs increased.
Positive_regulation (increased) of Gene_expression (Levels) of H4
3) Confidence 0.06 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2827364 Disease Relevance 1.01 Pain Relevance 0

General Comments

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